Effect of GuttaClear on Postoperative Pain After Root Canal Retreatment: A Randomized Clinical Trial

Objective:The aim of this study was to evaluate postoperative pain after non-surgical root canal retreatment with or without GuttaClear.Methods: Sixty participants were randomly distributed in this non-inferiority trial into two parallel single -blinded experimental groups (Group1: non-solvent, Group2: solvent). After root canal retreatment, the par-ticipants completed questionnaires using direct (numerical rating scales) and indirect (number of analgesics taken) measurements of postoperative pain at immediate, 6, 12, 24, 48, and 72 h post-retreatment. The pre-disposing postoperative pain factors were recorded and analysed using Generalized Estimating Equations to identify correlated factors (alpha=0.05).Results:The pain incidence was not significantly different between the groups at any time point. The highest incidence of postoperative pain occurred immediately after retreatment (35%) and then decreased to 15% at 24 h (P<0.05). The number of participants requiring analgesics was 6.67% in the non-solvent group and 9.99% in the solvent group which were similar between the groups. Patients with a history of previous postoperative pain were 21.6-fold more likely to have postoperative pain than those without (P<0.05).Conclusion:There was no difference in postoperative pain or analgesics required after root canal retreatment with or without using GuttaClear. This study is registered in ClinicalTrial.gov (NCT04326998).