From lymphatic endothelial cell migration to formation of tubular lymphatic vascular network

被引：4

作者：

Shiiya, Tomohiro ^{[1
]}

Hirashima, Masanori ^{[1
]}

机构：

[1] Niigata Univ, Grad Sch Med & Dent Sci, Div Pharmacol, Niigata, Japan

来源：

FRONTIERS IN PHYSIOLOGY | 2023年 / 14卷

关键词：

cell adhesion; cell polarization; chemotactic factor; lymphatic endothelial cell; migration; GROWTH-FACTOR-C; EMBRYONIC LYMPHANGIOGENESIS; VESSEL FORMATION; MATRIX; MORPHOGENESIS; INTEGRINS; GUIDANCE; ROLES;

D O I：

10.3389/fphys.2023.1124696

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

During development, lymphatic endothelial cell (LEC) progenitors differentiate from venous endothelial cells only in limited regions of the body. Thus, LEC migration and subsequent tube formation are essential processes for the development of tubular lymphatic vascular network throughout the body. In this review, we discuss chemotactic factors, LEC-extracellular matrix interactions and planar cell polarity regulating LEC migration and formation of tubular lymphatic vessels. Insights into molecular mechanisms underlying these processes will help in understanding not only physiological lymphatic vascular development but lymphangiogenesis associated with pathological conditions such as tumors and inflammation.

引用

页数：6

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