Antibacterial Effects of X-ray and MRI Contrast Media: An In Vitro Pilot Study

被引：4

作者：

Bronnimann, Michael P. ^{[1
]}

Hirzberger, Lea ^{[2
]}

Keller, Peter M. ^{[2
]}

Gsell-Albert, Monika ^{[2
]}

机构：

[1] Univ Bern, Bern Univ Hosp, Dept Diagnost Intervent & Paediat Radiol, Inselspital, CH-3010 Bern, Switzerland

[2] Univ Bern, Inst Infect Dis, CH-3010 Bern, Switzerland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期

关键词：

contrast media; anti-bacterial agents; microbial sensitivity tests; antibacterial effect; magnetic resonance imaging; interventional; minimally invasive surgical procedures; anti-infective agents; IODINE; AGENTS; GADOLINIUM; CHLORINE; GROWTH; PH;

D O I：

10.3390/ijms24043470

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some radiological contrast agents have been shown to have effects on bacterial growth. In this study, the antibacterial effect and mechanism of action of iodinated X-ray contrast agents (Ultravist 370, Iopamiro 300, Telebrix Gastro 300 and Visipaque) and complexed lanthanide MRI contrast solutions (MultiHance and Dotarem) were tested against six different microorganisms. Bacteria with high and low concentrations were exposed to media containing different contrast media for various lengths of time and at pH 7.0 and 5.5. The antibacterial effect of the media was examined in further tests using agar disk diffusion analysis and the microdilution inhibition method. Bactericidal effects were found for microorganisms at low concentrations and low pH. Reductions were confirmed for Staphylococcus aureus and Escherichia coli.

引用

页数：9

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