Bone Marrow Lesions and Magnetic Resonance Imaging-Detected Structural Abnormalities in Patients With Midfoot Pain and Osteoarthritis: A Cross-Sectional Study

被引:5
作者
Arnold, John B. [1 ,2 ,3 ]
Halstead, Jill [4 ,5 ]
Martin-Hervas, Carmen [6 ,7 ]
Grainger, Andrew J. [1 ,2 ,8 ,9 ]
Keenan, Anne-Maree [1 ,2 ]
Hill, Catherine L. [10 ,11 ]
Conaghan, Philip G. [1 ,2 ]
McGonagle, Dennis [1 ,2 ]
Redmond, Anthony C. [1 ,2 ]
机构
[1] Univ Leeds, Leeds, England
[2] NIHR Leeds Biomed Res Ctr, Leeds, England
[3] Univ South Australia, IIMPACT Hlth Allied Hlth & Human Performance, Adelaide, SA, Australia
[4] Univ Leeds, NIHR Leeds Biomed Res Ctr, Leeds, England
[5] Leeds Community Healthcare NHS Trust, Leeds, England
[6] Univ Autonoma Madrid, La Paz Univ Hosp, Madrid, Spain
[7] Ciber BBN, Biomed Res Networking Ctr Bioengn Biomat & Nanome, Madrid, Spain
[8] Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England
[9] Univ Cambridge, Cambridge, England
[10] Queen Elizabeth Hosp, Adelaide, SA, Australia
[11] Univ Adelaide, Adelaide, SA, Australia
基金
英国医学研究理事会;
关键词
MRI FINDINGS; KNEE PAIN; FOOT PAIN; SYNOVITIS; ASSOCIATION; PROGRESSION; OSTEOPHYTES; CARTILAGE; ENTHESES; EROSIONS;
D O I
10.1002/acr.24955
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To compare magnetic resonance imaging (MRI)-detected structural abnormalities in patients with symptomatic midfoot osteoarthritis (OA), patients with persistent midfoot pain, and asymptomatic controls, and to explore the association between MRI features, pain, and foot-related disability. Methods. One hundred seven adults consisting of 50 patients with symptomatic and radiographically confirmed midfoot OA, 22 adults with persistent midfoot pain but absence of radiographic OA, and 35 asymptomatic adults underwent 3T MRI of the midfoot and clinical assessment. MRIs were read for the presence and severity of abnormalities (bone marrow lesions [BMLs], subchondral cysts, osteophytes, joint space narrowing [JSN], effusion-synovitis, tenosynovitis, and enthesopathy) using the Foot Osteoarthritis MRI Score. Pain and foot-related disability were assessed with the Manchester Foot Pain and Disability Index. Results. The severity sum score of BMLs in the midfoot was greater in patients with midfoot pain and no signs of OA on radiography compared to controls (P = 0.007), with a pattern of involvement in the cuneiform-metatarsal joints similar to that in patients with midfoot OA. In univariable models, BMLs (rho = 0.307), JSN (rho = 0.423), and subchondral cysts (rho = 0.302) were positively associated with pain (P < 0.01). In multivariable models, MRI abnormalities were not associated with pain and disability when adjusted for covariates. Conclusion. In individuals with persistent midfoot pain but no signs of OA on radiography, MRI findings suggested an underrecognized prevalence of OA, particularly in the second and third cuneiform-metatarsal joints, where BML patterns were consistent with previously recognized sites of elevated mechanical loading. Joint abnormalities were not strongly associated with pain or foot-related disability.
引用
收藏
页码:1113 / 1122
页数:10
相关论文
共 47 条
  • [1] A population-based study of the association between hip bone marrow lesions, high cartilage signal, and hip and knee pain
    Ahedi, Harbeer
    Aitken, Dawn
    Blizzard, Leigh
    Cicuttini, Flavia M.
    Jones, Graeme
    [J]. CLINICAL RHEUMATOLOGY, 2014, 33 (03) : 369 - 376
  • [2] Midfoot osteoarthritis: potential phenotypes and their associations with demographic, symptomatic and clinical characteristics
    Arnold, J. B.
    Marshall, M.
    Thomas, M. J.
    Redmond, A. C.
    Menz, H. B.
    Roddy, E.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2019, 27 (04) : 659 - 666
  • [3] Foot and Leg Muscle Weakness in People With Midfoot Osteoarthritis
    Arnold, John B.
    Halstead, Jill
    Grainger, Andrew J.
    Keenan, Anne-Maree
    Hill, Catherine L.
    Redmond, Anthony C.
    [J]. ARTHRITIS CARE & RESEARCH, 2021, 73 (06) : 772 - 780
  • [4] The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sites
    Benjamin, M
    McGonagle, D
    [J]. JOURNAL OF ANATOMY, 2001, 199 : 503 - 526
  • [5] Osteoarthritic bone marrow lesions almost exclusively colocate with denuded cartilage: a 3D study using data from the Osteoarthritis Initiative
    Bowes, Michael A.
    McLure, Stewart W. D.
    Wolstenholme, Christopher B. H.
    Vincent, Graham R.
    Williams, Sophie
    Grainger, Andrew
    Conaghan, Philip G.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 (10) : 1852 - 1857
  • [6] High-resolution ultrasound of the midfoot: sonography is more sensitive than conventional radiography in detection of osteophytes and erosions in inflammatory and non-inflammatory joint disease
    Camerer, Mathis
    Ehrenstein, Boris
    Hoffstetter, Patrick
    Fleck, Martin
    Hartung, Wolfgang
    [J]. CLINICAL RHEUMATOLOGY, 2017, 36 (09) : 2145 - 2149
  • [7] Inter and intra-rater repeatability of the scoring of foot pain drawings
    Chatterton, Benjamin D.
    Muller, Sara
    Thomas, Martin J.
    Menz, Hylton B.
    Rome, Keith
    Roddy, Edward
    [J]. JOURNAL OF FOOT AND ANKLE RESEARCH, 2013, 6
  • [8] Evolution of synovitis in osteoarthritic knees and its association with clinical features
    de lange-Brokaar, J. E.
    Ioan-Facsinay, A.
    Yusuf, E.
    Kroon, H. M.
    Zuurmond, A. -M.
    Stojanovic-Susulic, V.
    Nelissen, R. G. H. H.
    Bloem, J. L.
    Kloppenburg, M.
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2016, 24 (11) : 1867 - 1874
  • [9] First metatarsophalangeal joint- MRI findings in asymptomatic volunteers
    Dietrich, Tobias Johannes
    Figueira da Silva, Flora Luciana
    de Abreu, Marcelo Rodrigues
    Klammer, Georg
    Pfirrmann, Christian W. A.
    [J]. EUROPEAN RADIOLOGY, 2015, 25 (04) : 970 - 979
  • [10] Symptomatic Course of Foot Osteoarthritis Phenotypes: An 18-Month Prospective Analysis of Community-Dwelling Older Adults
    Downes, Thomas J.
    Chesterton, Linda
    Whittle, Rebecca
    Roddy, Edward
    Menz, Hylton B.
    Marshall, Michelle
    Thomas, Martin J.
    [J]. ARTHRITIS CARE & RESEARCH, 2018, 70 (07) : 1107 - 1112