Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors

被引：0

作者：

Kalathoor, Sujay ^{[1
]}

Rajendran, Sakthi ^{[2
]}

Canella, Alessandro ^{[2
]}

Raval, Raju ^{[1
]}

Cripe, Timothy P. ^{[2
,3
,4
]}

Mardis, Elaine R. ^{[2
,5
]}

Rajappa, Prajwal ^{[2
,5
,6
]}

机构：

[1] Ohio State Univ, Coll Med, Columbus, OH USA

[2] Nationwide Childrens Hosp, Columbus, OH USA

[3] Nationwide Childrens Hosp, Ctr Childhood Canc & Blood Dis, Columbus, OH USA

[4] Nationwide Childrens Hosp, Div Hematol Oncol Blood & Marrow Transplant, Columbus, OH USA

[5] Nationwide Childrens Hosp, Inst Genom Med, Columbus, OH USA

[6] 575 Childrens Crossrd, Columbus, OH 43205 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2023年 / 374卷

基金：

美国国家卫生研究院;

关键词：

Glioma; CNS tumors; Myeloid cells; Single cell RNA sequencing; SUPPRESSOR-CELLS; REACTIVE OXYGEN; GLIOMA MICROENVIRONMENT; MALIGNANT PROGRESSION; IMMUNE-RESPONSES; DENDRITIC CELLS; IDO EXPRESSION; STROMAL CELLS; L-ARGININE; CANCER;

D O I：

10.1016/j.jneuroim.2022.578009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Central nervous system (CNS) tumors are the most common type of solid tumors in children and the leading cause of cancer deaths in ages 0-14. Recent advances in the field of tumor biology and immunology have underscored the disparate nature of these distinct CNS tumor types. In this review, we briefly introduce pediatric CNS tumors and discuss various components of the TME, with a particular focus on myeloid cells. Although most studies regarding myeloid cells have been done on adult CNS tumors and animal models, we discuss the role of myeloid cell heterogeneity in pediatric CNS tumors and describe how these cells may contribute to tumorigenesis and treatment response. In addition, we present studies within the last 5 years that highlight human CNS tumors, the utility of various murine CNS tumor models, and the latest multi-dimensional tools that can be leveraged to investigate myeloid cell infiltration in young adults and children diagnosed with select CNS tumors.

引用

页数：11