Cancer Therapy-Associated Pulmonary Hypertension and Right Ventricular Dysfunction: Etiologies and Prognostic Implications

被引：7

作者：

Leiva, Orly ^{[1
]}

Beaty, William ^{[2
]}

Soo, Steven ^{[3
]}

Agarwal, Manyoo A. ^{[4
]}

Yang, Eric H. ^{[5
]}

机构：

[1] NYU, Grossman Sch Med, Dept Med, Div Cardiol, New York, NY 10016 USA

[2] NYU, Grossman Sch Med, Dept Med, New York, NY 10016 USA

[3] NYU, Grossman Long Isl Sch Med, Dept Med, Mineola, NY 11501 USA

[4] Cleveland Clin Abu Dhabi, Heart Vasc & Thorac Inst, Cardiooncol Program, Abu Dhabi, U Arab Emirates

[5] Univ Calif Los Angeles, Dept Med, UCLA Cardiooncol Program, Div Cardiol, Los Angeles, CA 90095 USA

来源：

REVIEWS IN CARDIOVASCULAR MEDICINE | 2024年 / 25卷 / 03期

关键词：

cardio-oncology; cardiotoxicity; pulmonary hypertension; right ventricular dysfunction; ARTERIAL-HYPERTENSION; PLEURAL EFFUSION; DASATINIB; BOSUTINIB; IMATINIB; INTERFERON; INHIBITORS; DISEASE; PATIENT; DETERIORATION;

D O I：

10.31083/j.rcm2503087

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Advances in cancer therapies have improved oncologic outcomes but can potentially expose patients to risk of cardiovascular toxicity. While left ventricular (LV) dysfunction is a well-known cardiotoxicity of cancer therapy. Pulmonary hypertension (PH) and right ventricular (RV) dysfunction are seen with several cancer therapies, including alkylating agents, tyrosine kinase inhibitors (TKIs), and immunotherapy, and are associated with significant morbidity and mortality. Awareness and recognition of cancer therapy-associated PH and RV dysfunction is critical to identify underlying etiologies and institute the appropriate therapy. However, gaps exist in the current literature on the epidemiology of PH and RV dysfunction in cancer, underlying pathophysiology and optimal management strategies.

引用

页数：13

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