Circadian biology to advance therapeutics for mood disorders

被引：18

作者：

Bhatnagar, Apoorva ^{[1
,2
]}

Murray, Greg ^{[2
]}

Ray, Sandipan ^{[1
]}

机构：

[1] Indian Inst Technol Hyderabad, Dept Biotechnol, Sangareddy 502284, Telangana, India

[2] Swinburne Univ Technol, Ctr Mental Hlth, Melbourne, Vic, Australia

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2023年 / 44卷 / 10期

基金：

英国惠康基金;

关键词：

GENE-EXPRESSION; CLOCK; RHYTHMS; TIME; DEPRESSION; MELATONIN; METABOLISM; ACTIVATION; REWARD; ATLAS;

D O I：

10.1016/j.tips.2023.07.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mood disorders account for a significant global disease burden, and pharmacological innovation is needed as existing medications are suboptimal. A wide range of evidence implicates circadian and sleep dysfunction in the pathogenesis of mood disorders, and there is growing interest in these chronobiological pathways as a focus for treatment innovation. We review contemporary evidence in three promising areas in circadian-clock-based therapeutics in mood disorders: targeting the circadian system informed by mechanistic molecular advances; time-tailoring of medications; and personalizing treatment using circadian parameters. We also consider the limitations and challenges in accelerating the development of new circadian-informed pharmacotherapies for mood disorders.

引用

页码：689 / 704

页数：16

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