Cobalt(II)-Catalyzed C(sp3)-C(sp3) Coupling for the Direct Stereoselective Synthesis of 2-Deoxy-C-Glycosides from Glycals

被引：28
|
作者：
Zeng, Mingjie [1 ,2 ]
Yu, Changyue [2 ]
Wang, Yibing [2 ]
Wang, Jingjing [2 ]
Wang, Jiang [2 ,3 ]
Liu, Hong [1 ,2 ]
机构：
[1] China Pharmaceut Univ, 639 Longmian Ave, Nanjing 211198, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd, Shanghai 201203, Peoples R China
[3] Lingang Lab, Shanghai 200031, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 22期
基金：
中国国家自然科学基金;
关键词：
Cobalt Catalysis; C(sp(3))-C(sp(3)) Coupling; beta-Configuration; 2-Deoxy-C-Glycosides; Radical Reactions; C-GLYCOSIDES; STRATEGY;
D O I：
10.1002/anie.202300424
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a ligand-controlled Co-II-catalyzed C(sp(3))-C(sp(3)) coupling hydroalkylation for direct and beta-selective synthesis of 2-deoxy-C-glycosides from glycals. This reaction proceeds by a radical pathway for alkyl halide activation and is beta-selective through ligand control. This approach may inspire the development of further stereoselective coupling reactions with potential application in the field of carbohydrates.
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页数：6
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