Altered voxel-based and surface-based morphometry in inflammatory bowel disease

被引：3

作者：

Kornelsen, Jennifer ^{[1
,2
,3
]}

McIver, Theresa ^{[1
,3
,4
]}

Uddin, Md Nasir ^{[1
,7
,8
]}

Figley, Chase R. ^{[1
,2
]}

Marrie, Ruth Ann ^{[4
,5
]}

Patel, Ronak ^{[6
]}

Fisk, John D. ^{[9
]}

Carter, Sean ^{[4
]}

Graff, Lesley ^{[6
]}

Mazerolle, Erin L. ^{[10
]}

Bernstein, Charles N.

机构：

[1] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Radiol, Winnipeg, MB, Canada

[2] Univ Manitoba, Winnipeg Hlth Sci Ctr, Kleysen Inst Adv Med, Neurosci Res Program, Winnipeg, MB, Canada

[3] Univ Manitoba, IBD Clin & Res Ctr, Winnipeg, MB, Canada

[4] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Internal Med, Winnipeg, MB, Canada

[5] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Community Hlth Sci, Winnipeg, MB, Canada

[6] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Clin Hlth Psychol, Winnipeg, MB, Canada

[7] Univ Rochester, Sch Med & Dent, Dept Neurol, Rochester, NY USA

[8] Univ Rochester, Hajim Sch Engn & Appl Sci, Dept Biomed Engn, Rochester, NY USA

[9] Dalhousie Univ, Nova Scotia Hlth & Dept Psychiat, Psychol & Neurosci & Med, Halifax, NS, Canada

[10] St Francis Xavier Univ, Dept Psychol Comp Sci & Biol, Antigonish, NS, Canada

来源：

BRAIN RESEARCH BULLETIN | 2023年 / 203卷

关键词：

Inflammatory bowel disease; IBD; Crohn 's disease; Ulcerative colitis; Brain structure; Voxel-based morphometry; Surface-based morphometry; Cortical thickness; Cortical complexity; CORTICAL THICKNESS; CROHNS-DISEASE; FUNCTIONAL CONNECTIVITY; BRAIN INVOLVEMENT; FRACTAL DIMENSION; CORTEX;

D O I：

10.1016/j.brainresbull.2023.110771

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is characterized by inflammation of the gastrointestinal tract and is a disorder of the brain-gut axis. Neuroimaging studies of brain function and structure have helped better understand the relationships between the brain, gut, and comorbidity in IBD. Studies of brain structure have primarily employed voxel-based morphometry to measure grey matter volume and surface-based morphometry to measure cortical thickness. Far fewer studies have employed other surface-based morphometry metrics such as gyrification, cortical complexity, and sulcal depth. In this study, brain structure differences between 72 adults with IBD and 90 healthy controls were assessed using all five metrics. Significant differences were found for cortical thickness with the IBD group showing extensive leftlateralized thinning, and for cortical complexity with the IBD group showing greater complexity in the left fusiform and right posterior cingulate. No significant differences were found in grey matter volume, gyrification, or sulcal depth. Within the IBD group, a post hoc analysis identified that disease duration is associated with cortical complexity of the right supramarginal gyrus, albeit with a more lenient threshold applied.

引用

页数：9