Alternative splicing events and function in the tumor microenvironment: New opportunities and challenges

被引：8

作者：

Song, Xueyi ^{[1
,2
]}

Li, Xuehao ^{[3
]}

Ge, Yuexin ^{[1
,2
]}

Song, Jia ^{[1
,2
]}

Wei, Qian ^{[1
,2
]}

He, Miao ^{[1
,2
]}

Wei, Minjie ^{[1
,2
]}

Zhang, Yining ^{[4
]}

Chen, Tianbao ^{[5
]}

Zhao, Lin ^{[1
,2
]}

机构：

[1] China Med Univ, Sch Pharm, Dept Pharmacol, Shenyang 110122, Peoples R China

[2] China Med Univ, Liaoning Key Lab Mol targeted Antitumor drug Dev &, Shenyang 110122, Peoples R China

[3] China Med Univ, Affiliated Hosp 1, Dept thorac Surg, Shenyang, Peoples R China

[4] China Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Shenyang, Peoples R China

[5] Queens Univ Belfast, Sch Pharm, Nat Drug Discovery Grp, Belfast BT9 7BL, North Ireland

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2023年 / 123卷

基金：

中国国家自然科学基金;

关键词：

Alternative splicing; Tumor microenvironment; Cancer; PRE-MESSENGER-RNA; PATTERN-RECOGNITION RECEPTORS; TENASCIN-C; GENE; CANCER; IDENTIFICATION; EXPRESSION; PROTEINS; IL-33; FORM;

D O I：

10.1016/j.intimp.2023.110718

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alternative splicing controls gene expression at the transcriptional level, producing structurally and functionally distinct protein heterodimers. Aberrant alternative splicing greatly affects cell development and plays an important role in the invasion and metastasis of many types of cancer. Recently, it has been shown that alternative splicing can alter the tumor microenvironment and regulate processes such as remodeling, immunity, and inflammation in the tumor microenvironment. However, there is no comprehensive literature review of the complex relationship between alternative splicing and the tumor microenvironment. Therefore, this review aims to collect all the latest data on this topic and provide a new perspective on the therapeutic and potential prognostic markers of cancer.

引用

页数：11

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