Synthesis of amides directly from carboxylic acids and hydrazines

被引：1

作者：

Bhardwaj, Nivedita ^{[1
]}

Tripathi, Nancy ^{[1
]}

Kumar, Sanjay ^{[1
]}

Jain, Shreyans K. ^{[1
]}

机构：

[1] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 37期

关键词：

CATALYZED AMIDATION; AMINES; ALDEHYDES; ALCOHOLS; CARBENE; CHEMISTRY; PEPTIDES;

D O I：

10.1039/d3ob01268a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The method for amide bond synthesis described here utilizes carboxylic acids and hydrazines in the presence of a catalytic amount of ZnCl2. This is the first report that highlights the use of hydrazine as an amine partner for amide synthesis directly with carboxylic acids. Ammonia (gas) is the only by-product in this method. The methodology is simple and could help in the synthesis of peptides and natural product derivatives. Zinc chloride catalyzed amide synthesis using various aliphatic/aromatic, carboxylic acid and hydrazine derivatives.

引用

收藏

页码：7572 / 7579

页数：8

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