Integrins in human hepatocellular carcinoma tumorigenesis and therapy

被引:10
作者
Gao, Qiong [1 ]
Sun, Zhaolin [1 ,3 ]
Fang, Deyu [2 ]
机构
[1] Dalian Med Univ, Coll Basic Med Sci, Dalian 116044, Liaoning, Peoples R China
[2] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA
[3] Dalian Med Univ, Dept Pharmacol, Dalian 116044, Liaoning, Peoples R China
关键词
Integrins; Hepatocellular carcinoma; Antitumor therapy; EPITHELIAL-MESENCHYMAL TRANSITION; ENHANCES CELL-ADHESION; HEPATIC STELLATE CELLS; MAP-KINASE; SIGNALING PATHWAY; UP-REGULATION; ACTIVATION; MIGRATION; INVASION; PROMOTES;
D O I
10.1097/CM9.0000000000002459
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Integrins are a family of transmembrane receptors that connect the extracellular matrix and actin skeleton, which mediate cell adhesion, migration, signal transduction, and gene transcription. As a bi-directional signaling molecule, integrins can modulate many aspects of tumorigenesis, including tumor growth, invasion, angiogenesis, metastasis, and therapeutic resistance. Therefore, integrins have a great potential as antitumor therapeutic targets. In this review, we summarize the recent reports of integrins in human hepatocellular carcinoma (HCC), focusing on the abnormal expression, activation, and signaling of integrins in cancer cells as well as their roles in other cells in the tumor microenvironment. We also discuss the regulation and functions of integrins in hepatitis B virus-related HCC. Finally, we update the clinical and preclinical studies of integrin-related drugs in the treatment of HCC.
引用
收藏
页码:253 / 268
页数:16
相关论文
共 150 条
[1]   Targeting integrins for cancer management using nanotherapeutic approaches: Recent advances and challenges [J].
Ahmad, Khurshid ;
Lee, Eun Ju ;
Shaikh, Sibhghatulla ;
Kumar, Anuj ;
Rao, Kummara Madhusudana ;
Park, So-Yong ;
Jin, Jun O. ;
Han, Sung Soo ;
Choi, Inho .
SEMINARS IN CANCER BIOLOGY, 2021, 69 :325-336
[2]   Context-dependent EMT programs in cancer metastasis [J].
Aiello, Nicole M. ;
Kang, Yibin .
JOURNAL OF EXPERIMENTAL MEDICINE, 2019, 216 (05) :1016-1026
[3]   Integrin endosomal signalling suppresses anoikis [J].
Alanko, Jonna ;
Mai, Anja ;
Jacquemet, Guillaume ;
Schauer, Kristine ;
Kaukonen, Riina ;
Saari, Markku ;
Goud, Bruno ;
Ivaska, Johanna .
NATURE CELL BIOLOGY, 2015, 17 (11) :1412-1421
[4]  
Aoudjit Fawzi, 2012, Chemother Res Pract, V2012, P283181, DOI 10.1155/2012/283181
[5]   p53 regulates cytoskeleton remodeling to suppress tumor progression [J].
Araki, Keigo ;
Ebata, Takahiro ;
Guo, Alvin Kunyao ;
Tobiume, Kei ;
Wolf, Steven John ;
Kawauchi, Keiko .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 72 (21) :4077-4094
[6]   Integrin structure, allostery, and bidirectional signaling [J].
Arnaout, MA ;
Mahalingam, B ;
Xiong, JP .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2005, 21 :381-410
[7]   Hepatic Stellate Cells Induce Hepatocellular Carcinoma Cell Resistance to Sorafenib Through the Laminin-332/α3 Integrin Axis Recovery of Focal Adhesion Kinase Ubiquitination [J].
Azzariti, Amalia ;
Mancarella, Serena ;
Porcelli, Letizia ;
Quatrale, Anna Elisa ;
Caligiuri, Alessandra ;
Lupo, Luigi ;
Dituri, Francesco ;
Giannelli, Gianluigi .
HEPATOLOGY, 2016, 64 (06) :2103-2117
[8]   Therapeutic Targeting of the Tumor Microenvironment [J].
Bejarano, Leire ;
Jordao, Marta J. C. ;
Joyce, Johanna A. .
CANCER DISCOVERY, 2021, 11 (04) :933-959
[9]   Laminin-5 stimulates hepatocellular carcinoma growth through a different function of α6β4 and α3β1 integrins [J].
Bergamini, Carlo ;
Sgarra, Concetta ;
Trerotoli, Paolo ;
Lupo, Luigi ;
Azzariti, Amalia ;
Antonaci, Salvatore ;
Giannelli, Gianluigi .
HEPATOLOGY, 2007, 46 (06) :1801-1809
[10]   Nogo-B promotes tumor angiogenesis and provides a potential therapeutic target in hepatocellular carcinoma [J].
Cai, Hao ;
Saiyin, Hexige ;
Liu, Xing ;
Han, Dingding ;
Ji, Guoqing ;
Qin, Bo ;
Zuo, Jie ;
Shen, Suqin ;
Yu, Wenbo ;
Wu, Jiaxue ;
Wu, Yanhua ;
Yu, Long .
MOLECULAR ONCOLOGY, 2018, 12 (12) :2042-2054