Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy

被引:15
作者
Guo, Shihui [1 ]
Zhu, Xiao [1 ]
Huang, Ziyuan [1 ]
Wei, Chuzhong [1 ]
Yu, Jiaao [1 ]
Zhang, Lin [1 ]
Feng, Jinghua [1 ]
Li, Mingdong [2 ]
Li, Zesong [3 ]
机构
[1] Guangdong Med Univ, Marine Biomed Res Inst, Computat Oncol Lab, Zhanjiang 524023, Peoples R China
[2] Zibo Cent Hosp, Dept Gastroenterol, Zibo 255000, Peoples R China
[3] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2,Guangdong Prov Key Lab Sy, Shenzhen Inst Translat Med,Dept Urol,Shenzhen Key, Shenzhen, Peoples R China
基金
中国国家自然科学基金;
关键词
Chromosome instability; DNA damage; Genome stability; Tumor metastasis; Tumor therapy; DNA-DAMAGE RESPONSE; CHROMOSOMAL INSTABILITY; FANCONI-ANEMIA; NONCODING RNA; TUMORS; CELLS;
D O I
10.1016/j.biopha.2022.114036
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Genetic instability can be caused by external factors and may also be associated with intracellular damage. At the same time, there is a large body of research investigating the mechanisms by which genetic instability occurs and demonstrating the relationship between genomic stability and tumors. Nowadays, tumorigenesis development is one of the hottest research areas. It is a vital factor affecting tumor treatment. Mechanisms of genomic stability and tumorigenesis development are relatively complex. Researchers have been working on these aspects of research. To explore the research progress of genomic stability and tumorigenesis, development, and treatment, the authors searched PubMed with the keywords "genome instability" "chromosome instability" "DNA damage" "tumor spread" and "cancer treatment". This extracts the information relevant to this study. Results: This review introduces genomic stability, drivers of tumor development, tumor cell characteristics, tumor metastasis, and tumor treatment. Among them, immunotherapy is more important in tumor treatment, which can effectively inhibit tumor metastasis and kill tumor cells. Breakthroughs in tumorigenesis development studies and discoveries in tumor metastasis will provide new therapeutic techniques. New tumor treatment methods can effectively prevent tumor metastasis and improve the cure rate of tumors.
引用
收藏
页数:10
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