Tumour cell heterogeneity in triple-negative breast cancer cells affects response to cisplatin, but not doxorubicin

被引：5

作者：

Yaourtis, Andria M. ^{[1
]}

Levina, Aviva ^{[1
]}

Lay, Peter A. ^{[1
,2
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

[2] Univ Sydney, Sydney Analyt, Sydney, NSW 2006, Australia

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2023年 / 239卷

基金：

澳大利亚研究理事会;

关键词：

Breast cancer; MDA-MB-231; cells; Cell plasticity; Cisplatin; Doxorubicin; NANOPARTICLES; THERAPY;

D O I：

10.1016/j.jinorgbio.2022.112082

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumour cell heterogeneity affects cisplatin but not doxorubicin cytotoxicity in two phenotypes of the triple -negative breast cancer (TNBC) cell line, MDA-MB-231. A mesenchymal MDA-MB-231 phenotype was three times less sensitive to cisplatin than an epithelial-type phenotype from the same cell line, which has important implications in the success of TNBC chemotherapies.

引用

页数：3

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