Structural diversity and biological role of the 5' untranslated regions of picornavirus

被引:1
作者
Peng, Tingyu [1 ]
Yang, Fayu [1 ]
Yang, Fan [1 ]
Cao, Weijun [1 ]
Zheng, Haixue [1 ]
Zhu, Zixiang [1 ]
机构
[1] Lanzhou Univ, Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Anim Dis Control & Prevent,Coll Vet, Lanzhou 730000, Peoples R China
关键词
5' untranslated regions; picornavirus; structure; function; IRES; MOUTH-DISEASE VIRUS; RIBOSOME ENTRY SITE; HEPATITIS-C VIRUS; CRICKET PARALYSIS VIRUS; TRACT-BINDING-PROTEIN; TRANSLATION INITIATION-COMPLEXES; AVIAN ENCEPHALOMYELITIS VIRUS; INNATE IMMUNE-RESPONSE; ENCEPHALOMYOCARDITIS VIRUS; POLIOVIRUS RNA;
D O I
10.1080/15476286.2023.2240992
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The genomic arrangement of most picornavirus of the Picornaviridae family shares a similar monocistronic genomic pattern and a defining organizational feature. A defining feature of picornavirus is the presence of evolutionarily conserved and highly-structured RNA elements in untranslated regions (UTRs) at the genome' 5'and 3' ends, essential for viral replication and translation. Given the diversity and complexity of RNA structure and the limitations of molecular biology techniques, the functional characterization and biological significance of UTRs remain to be fully elucidated, especially for 5' UTR. Here, we summarize the current knowledge of the 5' UTR of picornavirus. This review focuses on the structural characterization and the biological function of the RNA secondary and tertiary structures in the 5' UTR of picornavirus. Understanding the role of the 5' UTR of picornavirus can provide a deep insight into the viral replication cycle and pathogenic mechanisms.
引用
收藏
页码:548 / 562
页数:15
相关论文
共 172 条
[91]   Neutralizing Ljungan virus antibodies in children with newly diagnosed type 1 diabetes [J].
Lundstig, Annika ;
McDonald, Sharia L. ;
Maziarz, Marlena ;
Weldon, William C. ;
Vaziri-Sani, Fariba ;
Lernmark, Ake ;
Nilsson, Anna-Lena .
JOURNAL OF GENERAL VIROLOGY, 2021, 102 (05)
[92]   INTERACTION OF A CELLULAR 57-KILODALTON PROTEIN WITH THE INTERNAL TRANSLATION INITIATION SITE OF FOOT-AND-MOUTH-DISEASE VIRUS [J].
LUZ, N ;
BECK, E .
JOURNAL OF VIROLOGY, 1991, 65 (12) :6486-6494
[93]   Persistence and chronic urinary shedding of the aphthovirus equine rhinitis A virus [J].
Lynch, Stacey E. ;
Gilkerson, James R. ;
Symes, Sally J. ;
Huang, Jin-an ;
Hartley, Carol A. .
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 2013, 36 (01) :95-103
[94]   Poliovirus 5′-terminal cloverleaf RNA is required in cis for VPg uridylylation and the initiation of negative-strand RNA synthesis [J].
Lyons, T ;
Murray, KE ;
Roberts, AW ;
Barton, DJ .
JOURNAL OF VIROLOGY, 2001, 75 (22) :10696-10708
[95]   TRANSFER RNA-LIKE STRUCTURES - STRUCTURE, FUNCTION AND EVOLUTIONARY SIGNIFICANCE [J].
MANS, RMW ;
PLEIJ, CWA ;
BOSCH, L .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 201 (02) :303-324
[96]   Mengovirus and encephalomyocarditis virus poly(C) tract lengths can affect virus growth in murine cell culture [J].
Martin, LR ;
Neal, ZC ;
McBride, MS ;
Palmenberg, AC .
JOURNAL OF VIROLOGY, 2000, 74 (07) :3074-3081
[97]   Mutational analysis of the mengovirus poly(C) tract and surrounding heteropolymeric sequences [J].
Martin, LR ;
Duke, GM ;
Osorio, JE ;
Hall, DJ ;
Palmenberg, AC .
JOURNAL OF VIROLOGY, 1996, 70 (03) :2027-2031
[98]   Tandem mengovirus 5' pseudoknots are linked to viral RNA synthesis, not poly(C)-mediated virulence [J].
Martin, LR ;
Palmenberg, AC .
JOURNAL OF VIROLOGY, 1996, 70 (11) :8182-8186
[99]   Identification and characterization of a cis-acting replication element (cre) adjacent to the internal ribosome entry site of foot-and-mouth disease virus [J].
Mason, PW ;
Bezborodova, SV ;
Henry, TM .
JOURNAL OF VIROLOGY, 2002, 76 (19) :9686-9694
[100]   LA AUTOANTIGEN ENHANCES AND CORRECTS ABERRANT TRANSLATION OF POLIOVIRUS RNA IN RETICULOCYTE LYSATE [J].
MEEROVITCH, K ;
SVITKIN, YV ;
LEE, HS ;
LEJBKOWICZ, F ;
KENAN, DJ ;
CHAN, EKL ;
AGOL, VI ;
KEENE, JD ;
SONENBERG, N .
JOURNAL OF VIROLOGY, 1993, 67 (07) :3798-3807