Structural diversity and biological role of the 5' untranslated regions of picornavirus

被引:1
作者
Peng, Tingyu [1 ]
Yang, Fayu [1 ]
Yang, Fan [1 ]
Cao, Weijun [1 ]
Zheng, Haixue [1 ]
Zhu, Zixiang [1 ]
机构
[1] Lanzhou Univ, Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Anim Dis Control & Prevent,Coll Vet, Lanzhou 730000, Peoples R China
关键词
5' untranslated regions; picornavirus; structure; function; IRES; MOUTH-DISEASE VIRUS; RIBOSOME ENTRY SITE; HEPATITIS-C VIRUS; CRICKET PARALYSIS VIRUS; TRACT-BINDING-PROTEIN; TRANSLATION INITIATION-COMPLEXES; AVIAN ENCEPHALOMYELITIS VIRUS; INNATE IMMUNE-RESPONSE; ENCEPHALOMYOCARDITIS VIRUS; POLIOVIRUS RNA;
D O I
10.1080/15476286.2023.2240992
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The genomic arrangement of most picornavirus of the Picornaviridae family shares a similar monocistronic genomic pattern and a defining organizational feature. A defining feature of picornavirus is the presence of evolutionarily conserved and highly-structured RNA elements in untranslated regions (UTRs) at the genome' 5'and 3' ends, essential for viral replication and translation. Given the diversity and complexity of RNA structure and the limitations of molecular biology techniques, the functional characterization and biological significance of UTRs remain to be fully elucidated, especially for 5' UTR. Here, we summarize the current knowledge of the 5' UTR of picornavirus. This review focuses on the structural characterization and the biological function of the RNA secondary and tertiary structures in the 5' UTR of picornavirus. Understanding the role of the 5' UTR of picornavirus can provide a deep insight into the viral replication cycle and pathogenic mechanisms.
引用
收藏
页码:548 / 562
页数:15
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