Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension

被引：2
作者：
Gerzen, Oksana P. [1 ]
Lisin, Ruslan V. [1 ]
Balakin, Alexander A. [1 ]
Mukhlynina, Elena A. [1 ]
Kuznetsov, Daniil A. [1 ]
Nikitina, Larisa V. [1 ]
Protsenko, Yuri L. [1 ]
机构：
[1] Russian Acad Sci, Inst Immunol & Physiol, Ural Branch, 106 Pervomayskaya st, Ekaterinburg 620049, Russia
来源：
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY | 2023年 / 44卷 / 04期
基金：
俄罗斯科学基金会;
关键词：
Pulmonary arterial hypertension; Monocrotaline; Right atrium; Right ventricle; Mechanical characteristics; Myosin; HEAVY-CHAIN ISOFORMS; CARDIAC MYOSIN; FORCE; RATS; MECHANISMS; TENSION;
D O I：
10.1007/s10974-023-09651-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pulmonary arterial hypertension (PAH) leads to changes in the pump function of the heart and causes right-sided myocardial hypertrophy and heart failure. This study was the first to compare the contractile characteristics of the multicellular myocardial preparations of the right atrium (RA) and right ventricle (RV) of male rats from the control group (CON) and the group with monocrotaline (MCT)-induced hypertrophy at the molecular and multicellular levels. In both RA and RV in MCT-treated rats, the fraction of motile filaments and the maximum sliding velocity of actin and reconstituted thin filaments over myosin decreased, and the ratio of alpha-/beta-myosin heavy chains (MHC) shifted towards beta-MHC. In the RA strips and RV trabeculae, the maximum shortening velocity, the extent of muscle shortening, the amplitude of isometric stress, the amount of work decreased. PAH leads to a greater drop in right atrial contractility than that of the ventricle.
引用
收藏
页码：299 / 309
页数：11
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