Plasma Glial Fibrillary Acidic Protein Is Associated with 18F-SMBT-1 PET: Two Putative Astrocyte Reactivity Biomarkers for Alzheimer's Disease

被引：16

作者：

Chatterjee, Pratishtha ^{[1
,2
]}

Dore, Vincent ^{[3
,4
]}

Pedrini, Steve ^{[2
,5
]}

Krishnadas, Natasha ^{[4
,6
]}

Thota, Rohith ^{[1
,7
]}

Bourgeat, Pierrick ^{[8
]}

Ikonomovic, Milos D. ^{[9
,10
]}

Rainey-Smith, Stephanie R. ^{[2
,5
,11
,12
]}

Burnham, Samantha C. ^{[8
]}

Fowler, Christopher ^{[6
]}

Taddei, Kevin ^{[2
,5
]}

Mulligan, Rachel ^{[4
]}

Ames, David ^{[13
,14
]}

Masters, Colin L. ^{[6
]}

Fripp, Jurgen ^{[3
]}

Rowe, Christopher C. ^{[4
,15
]}

Martins, Ralph N. ^{[1
,2
,5
,16
]}

Villemagne, Victor L. ^{[4
,17
]}

机构：

[1] Macquarie Univ, Macquarie Med Sch, 75 Talavera Rd, N Ryde, NSW 2109, Australia

[2] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia

[3] CSIRO, Australian eHlth Res Ctr, Brisbane, Qld, Australia

[4] Austin Hlth, Dept Mol Imaging & Therapy, Heidelberg, Vic, Australia

[5] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

[6] Univ Newcastle, Coll Hlth Med & Wellbeing, Sch Biomed Sci & Pharm, Newcastle, NSW, Australia

[7] Australian eHlth Res Ctr, Hlth & Biosecur Flagship, Herston, Qld, Australia

[8] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA USA

[9] Geriatr Res Educ & Clin Ctr, VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA

[10] Murdoch Univ, Ctr Hlth Ageing, Hlth Futures Inst, Murdoch, WA, Australia

[11] Australian Alzheimers Res Fdn, Sarich Neurosci Res Inst, Nedlands, WA, Australia

[12] Univ Western Australia, Sch Psychol Sci, Crawley, WA, Australia

[13] Natl Ageing Res Inst, Parkville, Vic, Australia

[14] Univ Melbourne, Acad Unit Psychiat Old Age, Melbourne, Vic, Australia

[15] Univ Melbourne, Florey Dept Neurosci & Mental Hlth, Parkville, Vic, Australia

[16] Univ Western Australia, Sch Psychiat & Clin Neurosci, Crawley, WA, Australia

[17] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2023年 / 92卷 / 02期

关键词：

Astrocyte reactivity; biomarkers; 18F-SMBT-1; glial fibrillary acidic protein; monoamine oxidase B; positron; emission tomography; MONOAMINE-OXIDASE-B; MILD COGNITIVE IMPAIRMENT; CENTRAL-NERVOUS-SYSTEM; LIFE-STYLE AIBL; H-3; L-DEPRENYL; AMYLOID-BETA; BRAIN; DEPOSITION; GFAP; PERFORMANCE;

D O I：

10.3233/JAD-220908

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Astrocyte reactivity is an early event along the Alzheimer's disease (AD) continuum. Plasma glial fibrillary acidic protein (GFAP), posited to reflect astrocyte reactivity, is elevated across theADcontinuum from preclinical to dementia stages. Monoamine oxidase-B (MAO-B) is also elevated in reactive astrocytes observed using F-18-SMBT-1 PET in AD. Objective: The objective of this study was to evaluate the association between the abovementioned astrocyte reactivity biomarkers. Methods: Plasma GFAP andA beta were measured using the Simoa((R)) platform in participants who underwent brain F-18-SMBT-1 and A beta-PET imaging, comprising 54 healthy control (13 A beta-PET+ and 41 A beta-PET-), 11 mild cognitively impaired (3 A beta-PET+ and 8 A beta-PET-) and 6 probable AD (5 A beta-PET+ and 1 A beta-PET-) individuals. Linear regressions were used to assess associations of interest. Results: Plasma GFAP was associated with F-18-SMBT-1 signal in brain regions prone to early A beta deposition in AD, such as the supramarginal gyrus (SG), posterior cingulate (PC), lateral temporal (LT) and lateral occipital cortex (LO). After adjusting for age, sex, APOE beta 4 genotype, and soluble A beta (plasma A beta 42/40 ratio), plasma GFAP was associated with F-18-SMBT-1 signal in the SG, PC, LT, LO, and superior parietal cortex (SP). On adjusting for age, sex, APOE beta 4 genotype and insoluble A beta (A beta-PET), plasma GFAP was associated with F-18-SMBT-1 signal in the SG. Conclusion: There is an association between plasma GFAP and regional F-18-SMBT-1 PET, and this association appears to be dependent on brain A beta load.

引用

页码：615 / 628

页数：14

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