PCL/Gelatin/Graphene Oxide Electrospun Nanofibers: Effect of Surface Functionalization on In Vitro and Antibacterial Response

被引:11
作者
Hamdan, Nazirah [1 ]
Khodir, Wan Khartini Wan Abdul [1 ,2 ]
Abd Hamid, Shafida [1 ,2 ]
Nasir, Mohd Hamzah Mohd [3 ]
Hamzah, Ahmad Sazali [4 ]
Cruz-Maya, Iriczalli [5 ]
Guarino, Vincenzo [5 ]
机构
[1] Int Islamic Univ Malaysia, Dept Chem, Kulliyyah Sci, Kuantan Campus, Kuantan 25200, Pahang, Malaysia
[2] Int Islamic Univ Malaysia, SYNTOF, Kulliyyah Sci, Kuantan Campus, Kuantan 25200, Pahang, Malaysia
[3] Int Islamic Univ Malaysia, Dept Biotechnol, Kulliyyah Sci, Kuantan Campus, Kuantan 25200, Pahang, Malaysia
[4] Univ Teknol MARA, Inst Sci, Shah Alam 40450, Selangor, Malaysia
[5] Natl Res Council Italy, Inst Polymers Composites & Biomat, Mostra Oltremare Pad 20,V le JF Kennedy 54, I-80125 Naples, Italy
关键词
polycaprolactone; nanofibers; electrospinning; graphene oxide; plasma treatment; antibacterial; GRAPHENE OXIDE; BACTERIAL ATTACHMENT; NANOCOMPOSITE; NANOSHEETS; SCAFFOLDS; NANOPARTICLES; OPTIMIZATION; COMBINATION; FABRICATION; RESISTANCE;
D O I
10.3390/nano13030488
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The emergence of resistance to pathogenic bacteria has resulted from the misuse of antibiotics used in wound treatment. Therefore, nanomaterial-based agents can be used to overcome these limitations. In this study, polycaprolactone (PCL)/gelatin/graphene oxide electrospun nanofibers (PGO) are functionalized via plasma treatment with the monomeric groups diallylamine (PGO-M1), acrylic acid (PGO-M2), and tert-butyl acrylate (PGO-M3) to enhance the action against bacteria cells. The surface functionalization influences the morphology, surface wettability, mechanical properties, and thermal stability of PGO nanofibers. PGO-M1 and PGO-M2 exhibit good antibacterial activity against Staphylococcus aureus and Escherichia coli, whereas PGO-M3 tends to reduce their antibacterial properties compared to PGO nanofibers. The highest proportion of dead bacteria cells is found on the surface of hydrophilic PGO-M1, whereas live cells are colonized on the surface of hydrophobic PGO-M3. Likewise, PGO-M1 shows a good interaction with L929, which is confirmed by the high levels of adhesion and proliferation with respect to the control. All the results confirm that surface functionalization can be strategically used as a tool to engineer PGO nanofibers with controlled antibacterial properties for the fabrication of highly versatile devices suitable for different applications (e.g., health, environmental pollution).
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页数:26
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共 165 条
  • [1] Characterization and mechanical properties of electrospun cellulose acetate/graphene oxide composite nanofibers
    Aboamera, Nada M.
    Mohamed, Alaa
    Salama, Ahmed
    Osman, T. A.
    Khattab, A.
    [J]. MECHANICS OF ADVANCED MATERIALS AND STRUCTURES, 2019, 26 (09) : 765 - 769
  • [2] Bacterial response to different surface chemistries fabricated by plasma polymerization on electrospun nanofibers
    Abrigo, Martina
    Kingshott, Peter
    McArthur, Sally L.
    [J]. BIOINTERPHASES, 2015, 10 (04) : 1 - 9
  • [3] Electrospun Polystyrene Fiber Diameter Influencing Bacterial Attachment, Proliferation, and Growth
    Abrigo, Martina
    Kingshott, Peter
    McArthur, Sally L.
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (14) : 7644 - 7652
  • [4] Graphene oxide incorporated polycaprolactone/chitosan/collagen electrospun scaffold: Enhanced osteogenic properties for bone tissue engineering
    Aidun, Amir
    Firoozabady, Alireza Safaei
    Moharrami, Mohammad
    Ahmadi, Ali
    Haghighipour, Nooshin
    Bonakdar, Shahin
    Faghihi, Shahab
    [J]. ARTIFICIAL ORGANS, 2019, 43 (10) : E264 - E281
  • [5] Akbari S., 2017, POLYOLEFINS J, V4, P213, DOI [10.22063/POJ.2017.1436, DOI 10.22063/POJ.2017.1436]
  • [6] XPS and structural studies of high quality graphene oxide and reduced graphene oxide prepared by different chemical oxidation methods
    Al-Gaashani, R.
    Najjar, A.
    Zakaria, Y.
    Mansour, S.
    Atieh, M. A.
    [J]. CERAMICS INTERNATIONAL, 2019, 45 (11) : 14439 - 14448
  • [7] Structural Characterization of Graphene Oxide: Surface Functional Groups and Fractionated Oxidative Debris
    Aliyev, Elvin
    Filiz, Volkan
    Khan, Muntazim M.
    Lee, Young Joo
    Abetz, Clarissa
    Abetz, Volker
    [J]. NANOMATERIALS, 2019, 9 (08)
  • [8] Synthesis of graphene oxides particle of high oxidation degree using a modified Hummers method
    Alkhouzaam, Abedalkader
    Qiblawey, Hazim
    Khraisheh, Majeda
    Atieh, Muataz
    Al-Ghouti, Mohammad
    [J]. CERAMICS INTERNATIONAL, 2020, 46 (15) : 23997 - 24007
  • [9] Synthesis of Electrospun TiO2 Nanofibers and Characterization of Their Antibacterial and Antibiofilm Potential against Gram-Positive and Gram-Negative Bacteria
    Ansari, Mohammad Azam
    Albetran, Hani Manssor
    Alheshibri, Muidh Hamed
    Timoumi, Abdelmajid
    Algarou, Norah Abdullah
    Akhtar, Sultan
    Slimani, Yassine
    Almessiere, Munirah Abdullah
    Alahmari, Fatimah Saad
    Baykal, Abdulhadi
    Low, It-Meng
    [J]. ANTIBIOTICS-BASEL, 2020, 9 (09): : 1 - 15
  • [10] Electrospun zein/graphene oxide nanosheet composite nanofibers with controlled drug release as antibacterial wound dressing
    Asadi, Hamid
    Ghaee, Azadeh
    Nourmohammadi, Jhamak
    Mashak, Arezou
    [J]. INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2020, 69 (03) : 173 - 185