Epstein-Barr Virus Strongly Associates With Pediatric Multiple Sclerosis, But Not Myelin Oligodendrocyte Glycoprotein-Antibody-Associated Disease

被引：8

作者：

Fadda, Giulia ^{[1
]}

Yea, Carmen ^{[2
]}

O'Mahony, Julia ^{[3
]}

Waters, Patrick ^{[4
]}

Yeh, E. Ann ^{[2
]}

Marrie, Ruth Ann ^{[5
]}

Arnold, Douglas ^{[6
]}

Bar-Or, Amit ^{[7
]}

Banwell, Brenda ^{[8
]}

机构：

[1] Univ Ottawa, Ottawa Hosp, Res Inst, Dept Med, Ottawa, ON, Canada

[2] Hosp Sick Children, Toronto, ON, Canada

[3] Cleveland Clin Fdn, Mellen Ctr Multiple Sclerosis, Cleveland, OH USA

[4] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford, England

[5] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Internal Med, Winnipeg, MB, Canada

[6] Montreal Neurol Inst, Montreal, PQ, Canada

[7] Univ Penn, Perelman Sch Med, Dept Neurol, 3400 Civ Ctr Blvd,Rm 763, Philadelphia, PA 19104 USA

[8] Childrens Hosp Philadelphia, Child Guidance Clin, Philadelphia, PA USA

来源：

ANNALS OF NEUROLOGY | 2024年 / 95卷 / 04期

关键词：

CHILDREN;

D O I：

10.1002/ana.26890

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Reported rates of Epstein-Barr virus (EBV) seropositivity in children meeting multiple sclerosis (MS) diagnostic criteria are considerably lower than those reported in adult-onset MS, putting in question a requisite role for EBV in MS development. As prior work preceded recognition of myelin oligodendrocyte glycoprotein-associated disease (MOGAD), we assessed viral serologies in 251 children with incident demyelination and prospectively ascertained diagnoses. When MOGAD was serologically accounted for, the prevalence of EBV infection among MS children exceeded 90%, whereas remote EBV infection was not associated with MOGAD risk. Together, these findings substantiate EBV's role across the MS spectrum, and support distinct pathobiological mechanisms in MS versus MOGAD.

引用

页码：700 / 705

页数：6

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