Dietary inflammatory index, genetic susceptibility and risk of incident dementia: a prospective cohort study from UK biobank

被引：13
作者：
Peng, Min [1 ,2 ,3 ]
Yuan, Shiqi [1 ,2 ]
Lu, Dan [1 ,2 ,3 ]
Ling, Yitong [1 ,2 ]
Huang, Xiaxuan [1 ,2 ]
Lyu, Jun [4 ,5 ]
Xu, Anding [1 ,2 ,3 ]
机构：
[1] Jinan Univ, Dept Neurol, Affiliated Hosp 1, Guangzhou, Peoples R China
[2] Jinan Univ, Stroke Ctr, Affiliated Hosp 1, Guangzhou, Peoples R China
[3] Jinan Univ, Clin Neurosci Inst, Affiliated Hosp 1, Guangzhou, Peoples R China
[4] Jinan Univ, Dept Clin Res, Affiliated Hosp 1, Guangzhou, Peoples R China
[5] Guangdong Prov Key Lab Tradit Chinese Med Informat, Guangzhou, Peoples R China
来源：
JOURNAL OF NEUROLOGY | 2023年 / 271卷 / 3期
关键词：
Alzheimer's disease; Dementia; Dietary inflammatory index; UK biobank; ALZHEIMERS-DISEASE; ASSOCIATION;
D O I：
10.1007/s00415-023-12065-7
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
BackgroundGenetic factors, diet and inflammation are associated with the development of dementia. In this study, we aimed at evaluating the impact of the dietary inflammatory index (DII) scores and genetic susceptibility on the development of dementia.MethodsThis prospective study involved 207,301 participants aged between 39 and 72 years from UK biobank. A web-based 24-h dietary questionnaire was collected at least once from participants between 2006 and 2012. The DII was calculated based on inflammatory effect score of nutrients. Individual AD-GRS (Alzheimer's disease genetic risk score) was calculated. Incident dementia was ascertained through hospital or death records.ResultsOf all 207,301 participants, 468 incident cases of all-cause dementia (165 AD, 91 VD and 26 FTD) were reported during a follow-up period of 11.4 years. The participants in the highest quintile (Q) of DII scores reported a higher risk for all-cause dementia (Q5 vs. Q3, hazard ratio (HR) = 1.702; 95% CI: 1.285-2.255) and VD (Q5 vs. Q3, HR = 2.266, 95% CI: 1.133-4.531) compared to participants in the Q3. Besides, when compared with the Q1, there was a higher risk for AD in the subjects of Q5 (Q5 vs. Q1, HR = 1.590; 95% CI: 1.004-2.519). There was a non-linear relationship between DII score and all-cause incidence (P for non-linear = 0.038) by restricted cubic splines. Subgroup analysis found that the increased risk for all-cause dementia and AD was more pronounced in the elderly, women, and higher educated population. Cox regression models indicated that compared with the participants who had a low AD-GRS risk and in the lowest tertile of DII, participants had a high AD-GRS and the highest tertile of DII were associated with a higher risk of AD (HR = 1.757, 95% CI: 1.082-2.855, P = 0.023).ConclusionsThe DII scores were independently associated with an augmented risk for all-cause dementia, AD and VD. Additionally, high AD-GRS with higher DII scores was significantly associated with a higher risk of AD.
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页码：1286 / 1296
页数：11
相关论文
共 32 条
[1]   Environmental Risk Factors for Early-Onset Alzheimer's Dementia and Frontotemporal Dementia: A Case-Control Study in Northern Italy [J].
Adani, Giorgia ;
Filippini, Tommaso ;
Garuti, Caterina ;
Malavolti, Marcella ;
Vinceti, Giulia ;
Zamboni, Giovanna ;
Tondelli, Manuela ;
Galli, Chiara ;
Costa, Manuela ;
Vinceti, Marco ;
Chiari, Annalisa .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2020, 17 (21) :1-18
[2]  
Brick J M, 1996, Stat Methods Med Res, V5, P215, DOI 10.1177/096228029600500302
[3]   The UK Biobank resource with deep phenotyping and genomic data [J].
Bycroft, Clare ;
Freeman, Colin ;
Petkova, Desislava ;
Band, Gavin ;
Elliott, Lloyd T. ;
Sharp, Kevin ;
Motyer, Allan ;
Vukcevic, Damjan ;
Delaneau, Olivier ;
O'Connell, Jared ;
Cortes, Adrian ;
Welsh, Samantha ;
Young, Alan ;
Effingham, Mark ;
McVean, Gil ;
Leslie, Stephen ;
Allen, Naomi ;
Donnelly, Peter ;
Marchini, Jonathan .
NATURE, 2018, 562 (7726) :203-+
[4]   Neuroinflammation in Alzheimer's disease: Current evidence and future directions [J].
Calsolaro, Valeria ;
Edison, Paul .
ALZHEIMERS & DEMENTIA, 2016, 12 (06) :719-732
[5]   Diet Inflammatory Index and Dementia Incidence A Population-Based Study [J].
Charisis, Sokratis ;
Ntanasi, Eva ;
Yannakoulia, Mary ;
Anastasiou, Costas A. ;
Kosmidis, Mary H. ;
Dardiotis, Efthimios ;
Gargalionis, Antonios N. ;
Patas, Kostas ;
Chatzipanagiotou, Stylianos ;
Mourtzinos, Ioannis ;
Tzima, Katerina ;
Hadjigeorgiou, Georgios ;
Sakka, Paraskevi ;
Kapogiannis, Dimitrios ;
Scarmeas, Nikolaos .
NEUROLOGY, 2021, 97 (24) :E2381-E2391
[6]   Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants [J].
Fan, Mengyu ;
Sun, Dianjianyi ;
Zhou, Tao ;
Heianza, Yoriko ;
Lv, Jun ;
Li, Liming ;
Qi, Lu .
EUROPEAN HEART JOURNAL, 2020, 41 (11) :1182-+
[7]   Dietary inflammatory index and memory function: population-based national sample of elderly Americans [J].
Frith, Emily ;
Shivappa, Nitin ;
Mann, Joshua R. ;
Hebert, James R. ;
Wirth, Michael D. ;
Loprinzi, Paul D. .
BRITISH JOURNAL OF NUTRITION, 2018, 119 (05) :552-558
[8]   Diet and Inflammation [J].
Galland, Leo .
NUTRITION IN CLINICAL PRACTICE, 2010, 25 (06) :634-640
[9]   Dietary Inflammatory Index and Sleep Quality in Southern Italian Adults [J].
Godos, Justyna ;
Ferri, Raffaele ;
Caraci, Filippo ;
Cosentino, Filomena I. I. ;
Castellano, Sabrina ;
Shivappa, Nitin ;
Hebert, James R. ;
Galvano, Fabio ;
Grosso, Giuseppe .
NUTRIENTS, 2019, 11 (06)
[10]   Association between the Dietary Inflammatory Index and Risk for Cancer Recurrence and Mortality among Patients with Breast Cancer [J].
Jang, Hyeonjeong ;
Chung, Min Sung ;
Kang, Shin Sook ;
Park, Yongsoon .
NUTRIENTS, 2018, 10 (08)
1234