Synthesis, Antifungal Activity, and Molecular Docking Study of Some Novel Bistriazole Derivatives

被引：1

作者：

Wang, Y. ^{[1
]}

Hu, Y. ^{[1
]}

Jiao, S. ^{[1
]}

Chen, R. ^{[1
]}

Zou, Z. ^{[1
]}

机构：

[1] Southeast Univ, Coll Chem & Chem Engn, Nanjing 211189, Peoples R China

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 06期

关键词：

1; 2; 3-triazole; 4-triazole; synthesis; antifungal activity; molecular docking study; BIOLOGICAL EVALUATION; DESIGN;

D O I：

10.1134/S107036322306018X

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper, 20 compounds containing bis-(1,2,3 and 1,2,4)-triazole structure were synthesized and their antifungal activities against Candida fungi and Aspergillus niger were analyzed in vitro. Some of the prepared compounds exhibited the most promising activity compared with voriconazole and amphotericin B. Molecular docking studies were performed to for additional substantiation of antifungal activity of these derivatives. So, these compounds are expected to provide new ideas for the development of antifungal drugs.

引用

页码：1455 / 1467

页数：13

共 26 条

[21] Emerging Issues in Antifungal Resistance [J].

Perfect, John R. ;

Ghannoum, Mahmoud .

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2020, 34 (04) :921-+

[22] Studies on the Anticonvulsant Activity and Influence on GABA-ergic Neurotransmission of 1,2,4-Triazole-3-thione-Based Compounds [J].

Plech, Tomasz ;

Kapron, Barbara ;

Luszczki, Jarogniew J. ;

Wujec, Monika ;

Paneth, Agata ;

Siwek, Agata ;

Kolaczkowski, Marcin ;

Zolnierek, Maria ;

Nowak, Gabriel .

MOLECULES, 2014, 19 (08) :11279-11299

[23] Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus [J].

Tian, Ye ;

Liu, Zhaoqiang ;

Liu, Jinghan ;

Huang, Boshi ;

Kang, Dongwei ;

Zhang, Heng ;

De Clercq, Erik ;

Daelemans, Dirk ;

Pannecouque, Christophe ;

Lee, Kuo-Hsiung ;

Chen, Chin-Ho ;

Zhan, Peng ;

Liu, Xinyong .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 151 :339-350

[24] Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates [J].

Yadav, Pinki ;

Lal, Kashmiri ;

Kumar, Lokesh ;

Kumar, Ashwani ;

Kumar, Anil ;

Paul, Avijit K. ;

Kumar, Rajnish .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 155 :263-274

[25] Triazole derivatives and their anti-tubercular activity [J].

Zhang, Shu ;

Xu, Zhi ;

Gao, Chuan ;

Ren, Qing-Cheng ;

Chang, Le ;

Lv, Zao-Sheng ;

Feng, Lian-Shun .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 138 :501-513

[26]

Zhou CH, 2012, CURR MED CHEM, V19, P239

← 1 2 3 →