Association Between COVID-19 Infection and Cardiac Biomarkers in Hospitalized Patients at a Tertiary Care Center

被引:2
作者
Bader, Mahmoud W. [1 ]
Adeen, Abdulqader M. Alaa [1 ]
Hetta, Omar E. [1 ]
Aloufi, Alwaleed K. [1 ]
Fallata, Muhannad H. [1 ]
Alsiraihi, Abdulaziz A. [1 ]
Ahmed, Mohamed E. [2 ]
Kinsara, Abdulhalim J. [1 ,3 ,4 ]
机构
[1] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Med, Jeddah, Saudi Arabia
[2] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Sci & Hlth Profess, Jeddah, Saudi Arabia
[3] Minist Natl Guard Hlth Affairs, Cardiol, Jeddah, Saudi Arabia
[4] Minist Natl Guard Hlth Affairs, King Abdullah Int Med Res Ctr, Jeddah, Saudi Arabia
关键词
risk factors; acute cardiac injury; beta natriuretic peptides (bnp); cardiac troponin; covid-19; MYOCARDIAL INJURY; TROPONIN; ILLNESS; DEATH;
D O I
10.7759/cureus.41527
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background The effects of coronavirus disease 2019 (COVID-19) on the cardiovascular system are well established. However, knowledge gaps in the clinical implications of cardiac involvement in COVID-19 patients are yet to be addressed. This study aimed to investigate acute cardiac injury (ACI) risk factors and outcomes associated with COVID-19 infection with cardiac involvement. Methodology In this retrospective study, we included hospitalized patients between March 2020 and May 2022 with confirmed COVID-19 infection and evidence of cardiac involvement.Results In total, 501 patients were included, of whom 396 (79%) had evidence of ACI. The median troponin level was 25.8 (interquartile range (IQR) = 10.8-71). Patients with evidence of ACI were significantly more likely to have diabetes mellitus (75% vs. 60%), cardiovascular disease (48% vs. 37%), chronic lung disease (22.2% vs. 12.4%), and chronic kidney disease (32.3% vs. 16.2%). Additionally, patients with ACI were significantly more likely to have cardiomegaly (60.6% vs. 44.8%) and bilateral lobe infiltrates (77.8% vs. 60%) on X-ray. Patients with ACI were significantly more likely to suffer from complications such as cardiogenic shock (5.3% vs. 0%), pneumonia (80.1% vs. 65.7%), sepsis (24.2% vs. 9.5%), and acute respiratory distress syndrome (33.1% vs. 8.6%). Patients with ACI were also significantly more likely to be admitted to the intensive care unit (ICU) (57% vs. 26.7%) and significantly more likely to die (38.1% vs. 11.4%). The results of the multivariate regression analysis indicated that mortality was significantly higher in patients with elevated troponin levels (adjusted odds ratio = 4.73; 95% confidence interval = 2.49-8.98).Conclusions In COVID-19-infected patients, old age, diabetes mellitus, cardiovascular disease, chronic lung disease, and chronic kidney disease were associated with an increased risk of ACI. The presence of ACI in the context of COVID-19 infection was noted to increase the risk for severe complications, such as cardiogenic shock, ICU admission, sepsis, and death.
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页数:10
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