Peripheral T-cell activation, Th17 cells, regulatory T-cells, and aortic aneurysm in people with HIV

被引：1

作者：

Hove-Skovsgaard, Malene ^{[1
]}

Hogh, Julie ^{[1
]}

Pham, Michael Huy Cuong ^{[2
]}

Knudsen, Andreas Dehlbaek ^{[1
]}

Gerstoft, Jan ^{[1
,3
]}

Ostrowski, Sisse Rye ^{[3
,4
]}

Kober, Lars ^{[2
,3
]}

Benfield, Thomas ^{[3
,5
]}

Kofoed, Klaus Fuglsang ^{[2
,3
,6
]}

Nielsen, Susanne Dam ^{[1
,3
,7
]}

机构：

[1] Copenhagen Univ Hosp, Heart Ctr, Dept Infect Dis, Rigshospitalet, Copenhagen, Denmark

[2] Copenhagen Univ Hosp, Heart Ctr, Dept Cardiol, Rigshospitalet, Copenhagen, Denmark

[3] Univ Copenhagen, Inst Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark

[4] Copenhagen Univ Hosp, Dept Clin Immunol, Rigshospitalet, Copenhagen, Denmark

[5] Copenhagen Univ Hosp, Hvidovre Hosp, Edept Infect Dis, Hvidovre, Denmark

[6] Copenhagen Univ Hosp, Dept Radiol, Rigshospitalet, Copenhagen, Denmark

[7] Copenhagen Univ Hosp, Rigshospitalet, DK-2100 Copenhagen, Denmark

来源：

AIDS | 2023年 / 37卷 / 11期

关键词：

D O I：

10.1097/QAD.0000000000003612

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Here, we investigate if peripheral T-cell activation and proportion of Th17 and T-regulatory cells (Tregs) are associated with aortic aneurysm or aortic diameter in people with HIV. Aorta was examined by computed tomography scans and T-cells by flow cytometry in 428 participants, and aortic aneurysm was found in 32 participants. None of the T-cell subsets were associated with aortic aneurysm, but activated T-cells and Tregs had opposite association to aorta diameter indicating an inverse impact.

引用

页码：1765 / 1767

页数：3

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