The role of fibromodulin in inflammatory responses and diseases associated with inflammation

被引:8
作者
Zhao, Feng [1 ,2 ]
Bai, Yang [1 ,2 ]
Xiang, Xuerong [1 ,2 ]
Pang, Xiaoxiao [1 ,2 ]
机构
[1] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Stomatol Hosp, Chongqing, Peoples R China
[2] Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Stomatol Hosp, Chongqing, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
fibromodulin; SLRPs; inflammatory diseases; inflammation; immune response; LEUCINE-RICH PROTEOGLYCANS; INHIBITS TENOGENIC DIFFERENTIATION; TENDON STEM/PROGENITOR CELLS; C-REACTIVE PROTEIN; EXTRACELLULAR-MATRIX; ARTICULAR-CARTILAGE; MORAXELLA-CATARRHALIS; C4B-BINDING PROTEIN; FACTOR-H; TEMPOROMANDIBULAR-JOINT;
D O I
10.3389/fimmu.2023.1191787
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Inflammation is an immune response that the host organism eliminates threats from foreign objects or endogenous signals. It plays a key role in the progression, prognosis as well as therapy of diseases. Chronic inflammatory diseases have been regarded as the main cause of death worldwide at present, which greatly affect a vast number of individuals, producing economic and social burdens. Thus, developing drugs targeting inflammation has become necessary and attractive in the world. Currently, accumulating evidence suggests that small leucine-rich proteoglycans (SLRPs) exhibit essential roles in various inflammatory responses by acting as an anti-inflammatory or pro-inflammatory role in different scenarios of diseases. Of particular interest was a well-studied member, termed fibromodulin (FMOD), which has been largely explored in the role of inflammatory responses in inflammatory-related diseases. In this review, particular focus is given to the role of FMOD in inflammatory response including the relationship of FMOD with the complement system and immune cells, as well as the role of FMOD in the diseases associated with inflammation, such as skin wounding healing, osteoarthritis (OA), tendinopathy, atherosclerosis, and heart failure (HF). By conducting this review, we intend to gain insight into the role of FMOD in inflammation, which may open the way for the development of new anti-inflammation drugs in the scenarios of different inflammatory-related diseases.
引用
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页数:14
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