Bile acid binds heart failure and inflammation

被引：2
|
作者：
Tong, Dan [1 ,2 ,3 ]
Hill, Joseph A. [1 ,2 ,3 ]
机构：
[1] UT Southwestern Med Ctr, Div Cardiol, Dallas, TX 75390 USA
[2] UT Southwestern Med Ctr, Harry S Moss Heart Ctr, Dallas, TX 75390 USA
[3] UT Southwestern Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA
来源：
NATURE METABOLISM | 2023年 / 5卷 / 08期
关键词：
D O I：
10.1038/s42255-023-00836-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Mao et al. discover that heart failure-associated metabolic derangement results in cardiomyocyte cholesterol overload and accumulation of bile acid intermediates, which in turn trigger mitochondrial damage and inflammatory activation and thus promote heart failure.
引用
收藏
页码：1260 / 1261
页数：2
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