Impact of COVID-19 and vaccination on first and second trimester screening results

被引：1

作者：

Hantoushzadeh, Sedigheh ^{[1
]}

Younesi, Sarang ^{[2
]}

Amin, Mohammad Mahdi Taheri ^{[2
]}

Saadati, Pourandokht ^{[2
]}

Jamali, Soudabeh ^{[2
]}

Nassiri, Saina ^{[3
]}

Modarresi, Mohammad-Hossein ^{[5
]}

Savad, Shahram ^{[2
]}

Delshad, Saeed ^{[2
]}

Meiguni, Zahra Soleiman ^{[1
]}

Amidi, Saloomeh ^{[2
,4
]}

Navidpour, Fariba ^{[2
]}

Yazdani, Bahareh ^{[2
]}

Farani, Ali Karimi

Saleh, Maasoumeh ^{[2
,3
]}

Ghafouri-Fard, Soudeh ^{[6
]}

机构：

[1] Univ Tehran Med Sci, Family Hlth Res Inst, Vali Easr Reprod Hlth Res Ctr, Tehran, Iran

[2] Nilouu Lab, Tehran, Iran

[3] Univ Tehran Med Sci, Fac Med, Dept Gynecol & Obstet, Tehran, Iran

[4] Univ Tehran Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

[5] Univ Tehran Med Sci, Dent Fac, Teharn, Iran

[6] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran

来源：

CYTOKINE | 2023年 / 168卷

关键词：

First trimester screening; Second trimester screening; COVID-19; Vaccine;

D O I：

10.1016/j.cyto.2023.156228

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

COVID-19 has been shown to affect pregnant women. Since pregnant women are at risk of this infection, vaccination against COVID-19 has been suggested as an imperative way to diminish rate of COVID-19 in this population. In the current observational study, we have collected data of first and second trimester screening (FTS and STS) from pregnant women who were infected with SARS-CoV-2 and/or vaccinated against COVID-19 during their pregnancy, and compared this data with a group of control pregnant women. The cohort included 4612 and 2426 women referred for FTS and STS, respectively. There was no significant difference in median values of Pregnancy-associated plasma protein A (PAPP-A) and human chorionic gonadotropin-beta subunit (beta HCG) between infected women and controls. Moreover, these levels were not different between "Infected + vaccinated" and "Only vaccinated" groups. However, median values of PAPP-A and beta HCG were higher in "Infected + vaccinated" and "Only vaccinated" groups compared with "Infected" and "Control" groups (P < 0.001). Median values of unconjugated Estriol (uE3) and beta HCG markers were not different between "Only vaccinated" and "Control" groups, yet both markers were elevated in "Infected" and "Infected + vaccinated" groups compared with other groups. AFP values were higher in "Infected" group (P = 0.012). However, multiple of the median (MoM) and risk of open spina bifida (OSB) were not affected. Finally, median of calculated risk of trisomy 18 was lower in "Infected" and "Vaccinated" groups compared with controls (P = 0.007). Moreover, AstraZeneca and Sinopharm vaccines were associated with elevation of the calculated risk values of trisomy 21 and trisomy 18 (P < 0.001). While Sinopharm did not affect nuchal translucency (NT) and NT MoM (P = 0.13), AstraZeneca and Barakat increased and decreased these values, respectively (P values = 0.0027 and 0.015, respectively). Taken together, COVID-19 during pregnancy might be associated with some adverse obstetric outcomes. Besides, vaccination against this infection might affect the results of STS or FTS.

引用

页数：5

共 9 条

[1] COVID-19 and pregnancy: An umbrella review of clinical presentation, vertical transmission, and maternal and perinatal outcomes [J].