Rhythms from Two Competing Periodic Sources Embedded in an Excitable Medium

被引：8

作者：

Diagne, Khady ^{[1
]}

Bury, Thomas M. ^{[2
]}

Deyell, Marc W. ^{[3
,4
]}

Laksman, Zachary ^{[3
,4
]}

Shrier, Alvin ^{[2
]}

Bub, Gil ^{[2
]}

Glass, Leon ^{[2
]}

机构：

[1] McGill Univ, Dept Quantitat Life Sci, 550 Sherbrooke W, Montreal, PQ H3A 1E3, Canada

[2] McGill Univ, Dept Physiol, 3655 Promenade Sir William Osler, Montreal, PQ H3G 1Y6, Canada

[3] Univ British Columbia, Div Cardiol, Vancouver, BC V6E 1M7, Canada

[4] Univ British Columbia, Ctr Cardiovasc Innovat, Vancouver, BC V6E 1M7, Canada

来源：

PHYSICAL REVIEW LETTERS | 2023年 / 130卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

DYNAMICS; PATTERNS; WAVES; MODEL;

D O I：

10.1103/PhysRevLett.130.028401

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

In an excitable medium, a stimulus generates a wave that propagates in space until it reaches the boundary or collides with another wave and annihilates. We study the dynamics generated by two periodic sources with different frequencies in excitable cardiac tissue culture using optogenetic techniques. The observed rhythms, which can be modeled using cellular automata and studied analytically, show unexpected regularities related to classic results in number theory. We apply the results to identify cardiac arrhythmias in people that are due to a putative mechanism of two competing pacemakers.

引用

页数：5

共 23 条

[1] ON THE ARITHMETIC OF PHASE LOCKING - COUPLED NEURONS AS A LATTICE ON R2 [J].