Systemic Lupus Erythematosus-related Lung Disease

被引:3
作者
Bendstrup, Elisabeth [1 ,2 ]
Lynn, Evelyn [3 ,4 ]
Troldborg, Anne [5 ,6 ]
机构
[1] Aarhus Univ Hosp, Ctr Rare Lung Dis, Dept Resp Dis & Allergy, Palle Juul-Jensens Blvd 99, DK-8200 Aarhus N, Denmark
[2] Aarhus Univ, Dept Clin Med, Aarhus, Denmark
[3] St Vincents Univ Hosp, Dept Resp Med, Dublin, Ireland
[4] Univ Coll Dublin, Sch Med, Dublin, Ireland
[5] Aarhus Univ Hosp, Dept Rheumatol, Aarhus, Denmark
[6] Aarhus Univ, Biomed, Aarhus, Denmark
关键词
systemic lupus erythematosus; acute lupus pneumonitis; alveolar hemorrhage; pleural effusion; serositis; shrinking lung syndrome; interstitial lung disease; pulmonary hypertension; pulmonary embolism; PULMONARY ARTERIAL-HYPERTENSION; DIFFUSE ALVEOLAR HEMORRHAGE; ACUTE REVERSIBLE HYPOXEMIA; CONNECTIVE-TISSUE DISEASE; US COHORT LUMINA; SHRINKING LUNG; RISK-FACTORS; CLINICAL CHARACTERISTICS; VENOUS THROMBOEMBOLISM; INITIAL MANIFESTATION;
D O I
10.1055/s-0044-1782653
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Systemic Lupus Erythematosus (SLE) is a multifaceted, multisystem autoimmune disorder with diverse clinical expressions. While prevalence reports vary widely, pulmonary involvement accounts for significant morbidity and mortality in SLE. This comprehensive review explores the spectrum of pulmonary disease in SLE, including upper airway manifestations (e.g., laryngeal affection), lower airway conditions (e.g., bronchitis, bronchiolitis, bronchiectasis), parenchymal diseases (e.g., interstitial lung disease, acute lupus pneumonitis, diffuse alveolar hemorrhage), pleural diseases (e.g., serositis, shrinking lung syndrome), and vascular diseases (e.g., pulmonary arterial hypertension, pulmonary embolism, acute reversible hypoxemia syndrome). We discuss diagnostic modalities, treatment strategies, and prognosis for each pulmonary manifestation. With diagnostics remaining a challenge and with the absence of standardized treatment guidelines, we emphasize the need for evidence-based guidelines to optimize patient care and improve outcomes in this complex disease.
引用
收藏
页码:386 / 396
页数:11
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