Visible light-induced metal-free cascade denitrogenative borylation and iodination of nitroarenes

被引：4

作者：

Li, Jun-Wei ^{[1
]}

Duan, Tian-Shun ^{[1
]}

Sun, Bing ^{[1
]}

Zhang, Fang-Lin ^{[1
]}

机构：

[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 14期

基金：

中国国家自然科学基金;

关键词：

CATALYZED BORYLATION; ARYL HALIDES; POTENT; REDUCTION; DESIGN;

D O I：

10.1039/d4ob00309h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method was developed for the one-pot construction of C-B and C-I via visible light-induced transformation of nitroarenes. This protocol relies on the photochemical properties of nitroarenes under visible light, followed by reduction with B2pin2 and diazotization with tBuONO. An array of arylboronates and iodobenzenes were constructed smoothly after excitation with purple LEDs at room temperature. In addition, the synthetic utility of this method was further demonstrated in the late-stage modification of a drug molecule. The advantages of this strategy include metal-free system, mild reaction conditions and acceptable substrate scope. A simple, efficient, green method for converting nitroarenes into haloarenes and arylboronates under light irradiation.

引用

页码：2819 / 2823

页数：5

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