Comorbid Conditions and Physical Function in Adults With Multiple Sclerosis

Objective: We examined the total number of comorbid conditions as a correlate of physical function in persons with multiple sclerosis (MS). We further identified the presence of common comorbid conditions and examined physical function outcomes based on presence or absence of the comorbid conditions in persons with MS. Participants: Two hundred seven persons with MS (N=207) completed the study. Main Outcome Measures: Participants provided demographic, clinical, and comorbidity information. Participants then completed the 6-minute walk (6MW), timed 25-foot walk (T25FW), timed Up and Go (TUG), and short physical performance battery (SPPB). Results: The number of comorbid conditions was associated with 6MW, T25FW, TUG, and SPPB scores (all P <=.001). Persons with MS who had hypertension performed worse on the 6MW, T25FW, TUG, and SPPB than persons without hypertension. Persons who had osteoarthritis performed worse on the 6MW, T25FW, and SPPB than persons without osteoarthritis. Conclusions: The results demonstrate that persons who report more comorbid conditions have worse physical function, and this may largely be associated with hypertension or osteoarthritis. There are opportunities for the design of behavioral interventions that target physical activity and/ or diet for improving physical function via comorbid conditions in persons with MS. Archives of Physical Medicine and Rehabilitation 2024;105:251-7 (c) 2023 by the American Congress of Rehabilitation Medicine.