This study describes the development of a novel disposable and low-cost electrochemical platform for detecting the antibiotic ceftriaxone. The screen-printed electrode has been modified with a novel hybrid nanostructure containing silicon oxide (SiO2), zirconium oxide (ZrO2), and nitrogen-doped carbon quantum dots (Cdot-N). Different techniques like Fourier-transform infrared spectroscopy, Raman spectroscopy, and transmission electron microscopy characterized the hybrid nanostructure used in the sensor surface modifier material. The hybrid nanostructure showed an excellent synergistic effect that contributed to the oxidation reaction of ceftriaxone. The screen-printed electrode modified with SiO2/ZrO2/Cdot-N nanostructure presented high sensitivity with a detection limit of 0.2 nmol L-1 in the linear range of 0.0078-40.02 mu mol L-1. The measurements have been performed by square wave voltammetry technique. Studies on real samples of synthetic urine, urine, and tap water showed 95%-105% recovery without applying any sample pretreatment. The sensor demonstrated excellent selectivity in the antibiotic ceftriaxone determination in the presence of possible interferences cationic, Na+, K+, Ca2+, Mg2+, Cu2+, Pb2+, Mn2+, Zn2+, Co2+, and biological, glucose, caffeine, uric acid, and ascorbic acid. The developed sensor becomes a selective, sensitive, and applicable tool in determining the antibiotic ceftriaxone.
