Calming the Nerves via the Immune Instructive Physiochemical Properties of Self-Assembling Peptide Hydrogels

被引：10

作者：

Mahmoudi, Negar ^{[1
,2
,3
,4
]}

Mohamed, Elmira ^{[1
]}

Dehnavi, Shiva Soltani ^{[1
,2
]}

Aguilar, Lilith M. Caballero ^{[1
,3
,4
]}

Harvey, Alan R. ^{[5
,6
]}

Parish, Clare L. ^{[7
]}

Williams, Richard J. ^{[8
]}

Nisbet, David R. ^{[1
,3
,4
,9
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Lab Adv Biomat, Canberra, ACT 2601, Australia

[2] Australian Natl Univ, ANU Coll Engn & Comp Sci, Canberra, ACT 2601, Australia

[3] Univ Melbourne, Graeme Clark Inst, Melbourne, Vic 3010, Australia

[4] Univ Melbourne, Fac Engn & Informat Technol, Dept Biomed Engn, Melbourne, Vic 3010, Australia

[5] Univ Western Australia, Sch Human Sci, Perth, WA 6009, Australia

[6] Perron Inst Neurol & Translat Sci, Perth, WA 6009, Australia

[7] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic 3010, Australia

[8] Deakin Univ, Sch Med, IMPACT, Geelong, Vic 3217, Australia

[9] Univ Melbourne, Fac Med Dent & Hlth Sci, Melbourne Med Sch, Melbourne, Vic 3010, Australia

来源：

ADVANCED SCIENCE | 2024年 / 11卷 / 05期

基金：

英国医学研究理事会;

关键词：

bioactive scaffolds; foreign body reaction; neural regeneration; self-assembling peptide-based hydrogels; tissue engineering; CENTRAL-NERVOUS-SYSTEM; NEURAL STEM-CELLS; TRAUMATIC BRAIN-INJURY; SPINAL-CORD-INJURY; CONTROLLED-RELEASE; GROWTH-FACTOR; IN-VIVO; EXTRACELLULAR-MATRIX; NEUROTROPHIC FACTORS; NANOFIBER HYDROGEL;

D O I：

10.1002/advs.202303707

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Current therapies for the devastating damage caused by traumatic brain injuries (TBI) are limited. This is in part due to poor drug efficacy to modulate neuroinflammation, angiogenesis and/or promoting neuroprotection and is the combined result of challenges in getting drugs across the blood brain barrier, in a targeted approach. The negative impact of the injured extracellular matrix (ECM) has been identified as a factor in restricting post-injury plasticity of residual neurons and is shown to reduce the functional integration of grafted cells. Therefore, new strategies are needed to manipulate the extracellular environment at the subacute phase to enhance brain regeneration. In this review, potential strategies are to be discussed for the treatment of TBI by using self-assembling peptide (SAP) hydrogels, fabricated via the rational design of supramolecular peptide scaffolds, as an artificial ECM which under the appropriate conditions yields a supramolecular hydrogel. Sequence selection of the peptides allows the tuning of these hydrogels' physical and biochemical properties such as charge, hydrophobicity, cell adhesiveness, stiffness, factor presentation, degradation profile and responsiveness to (external) stimuli. This review aims to facilitate the development of more intelligent biomaterials in the future to satisfy the parameters, requirements, and opportunities for the effective treatment of TBI. Modulating the physicochemical properties of self-assembled peptide (SAP) hydrogels such as charge, hydrophobicity/hydrophilicity, cell adhesiveness, stiffness, therapeutic/growth factor presentation, and responsiveness to (external) stimuli can reduce neuroinflammatory responses and enhance neuroprotection in the treatment of traumatic brain injury.image

引用

页数：23

共 288 条

[1] Biodegradable Neuro-Compatible Peptide Hydrogel Promotes Neurite Outgrowth, Shows Significant Neuroprotection, and Delivers Anti-Alzheimer Drug [J].