Path towards mRNA delivery for cancer immunotherapy from bench to bedside

被引：12

作者：

Chen, Wenfei ^{[1
,2
,3
]}

Zhu, Yining ^{[2
,3
,4
]}

He, Jinhan ^{[1
]}

Sun, Xun ^{[2
,3
]}

机构：

[1] Sichuan Univ, West China Hosp, Inst Metab Dis & Pharmacotherapy, Dept Pharm, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug,Educ Minist, Chengdu 610041, Peoples R China

[3] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China

[4] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21218 USA

来源：

THERANOSTICS | 2024年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

TUMOR-ASSOCIATED ANTIGEN; DENDRITIC CELLS; LIPID NANOPARTICLES; T-LYMPHOCYTES; IN-VITRO; VACCINE; EXPRESSION; MACROPINOCYTOSIS; ELECTROPORATION; INTERLEUKIN-12;

D O I：

10.7150/thno.89247

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Messenger RNA (mRNA) has emerged as a promising therapeutic agent for the prevention and treatment of various diseases. mRNA vaccines, in particular, offer an alternative approach to conventional vaccines, boasting high potency, rapid development capabilities, cost-effectiveness, and safe administration. However, the clinical application of mRNA vaccines is hindered by the challenges of mRNA instability and inefficient in vivo delivery. In recent times, remarkable technological advancements have emerged to address these challenges, utilizing two main approaches: ex vivo transfection of dendritic cells (DCs) with mRNA and direct injection of mRNA-based therapeutics, either with or without a carrier. This review offers a comprehensive overview of major non-viral vectors employed for mRNA vaccine delivery. It showcases notable preclinical and clinical studies in the field of cancer immunotherapy and discusses important considerations for advancing these promising vaccine platforms for broader therapeutic applications. Additionally, we provide insights into future possibilities and the remaining challenges in mRNA delivery technology, emphasizing the significance of ongoing research in mRNA-based therapeutics.

引用

页码：96 / 115

页数：20

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