Synthesis and evaluation of antipyrine derivatives bearing a thiazole moiety as antibacterial and antifungal agents

被引：7
作者：
Abbas, Samir Y. [1 ]
Abd El-Aziz, Maha M. [2 ]
Awad, Samir M. [2 ]
Mohamed, Mosaad S. [2 ]
机构：
[1] Natl Res Ctr, Organometall & Organometalloid Chem Dept, Cairo, Egypt
[2] Helwan Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Cairo, Egypt
来源：
SYNTHETIC COMMUNICATIONS | 2023年 / 53卷 / 21期
关键词：
Antibacterial and antifungal activities; antipyrine; thiosemicarbazones; thiazoles; BIOLOGICAL EVALUATION; DESIGN; SERIES; INHIBITORS; POTENT;
D O I：
10.1080/00397911.2023.2248306
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
One of the best ways to design new biocidal agents is synthesizing hybrid molecules. So, new series of antipyrine-bearing thiazole moiety were synthesized using 4-antipyrinecarboxaldehyde thiosemicarbazones 1a-e. Cyclization of thiosemicarbazone derivatives 1a-e with ethyl 2-chloroacetate, ethyl 2-chloropropanoate, 1-chloropropan-2-one (chloroacetone) and 2-bromo-1-phenylethanone (phenacyl bromide) afforded the corresponding thiazolidin-4-ones 2a-e, 5-methyl-thiazolidin-4-ones 3a-e, 4-methylthiazoles 4a-e and 4-phenylthiazoles 5a-e, respectively. The antibacterial and antifungal activates for the synthesized compounds were investigated. [GRAPHICS] .
引用
收藏
页码：1812 / 1822
页数：11
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