Viral evolution of SIV chimpanzee toward HIV-1 using humanized mice

被引:0
|
作者
Curlin, James Z. [1 ,2 ]
Schmitt, Kimberly [1 ]
Remling-Mulder, Leila [1 ]
Tibbitts, Corina Valencia [3 ]
O'Connor, Shelby [3 ]
Marx, Preston [4 ,5 ]
Akkina, Ramesh [1 ,6 ]
机构
[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO USA
[2] Univ Colorado Anschutz Med Campus, Dept Med, ADEAR Training Program, Aurora, CO USA
[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pathol & Lab Med, Madison, WI USA
[4] Sch Publ Hlth & Trop Med, Dept Trop Med, New Orleans, LA USA
[5] Tulane Natl Primate Res Ctr, Covington, LA USA
[6] Colorado State Univ, Dept Microbiol Immunol & Pathol, 1619 Campus Delivery, Ft Collins, CO 80521 USA
关键词
HIV-1; hu-HSC mice; serial passaging; SIVcpzMB897; viral evolution; MUCOSAL TRANSMISSION; ADAPTATION; VIRUS; MODEL;
D O I
10.1111/jmp.12675
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4(+) T cell decline, and analyzing genetic changes. Four serial passages showed many non-synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.
引用
收藏
页码:294 / 297
页数:4
相关论文
共 50 条
  • [41] HIV-1 Vpr: Regulator of Viral Survival
    Thieu, Khanh P.
    Morrow, Matthew P.
    Shedlock, Devon J.
    Schoenly, Kimberly A.
    Mallilankaraman, Karthikbabu
    Choo, Andrew Y.
    Fagone, Paolo
    Weiner, David B.
    Muthumani, Karuppiah
    CURRENT HIV RESEARCH, 2009, 7 (02) : 153 - 162
  • [42] Site-Specific Evolutionary Rate Shifts in HIV-1 and SIV
    Gelbart, Maoz
    Stern, Adi
    VIRUSES-BASEL, 2020, 12 (11):
  • [43] Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization
    Crooks, Emma T.
    Jiang, Pengfei
    Franti, Michael
    Wong, Sharon
    Zwick, Michael B.
    Hoxie, James A.
    Robinson, James E.
    Moore, Penny L.
    Binley, James M.
    VIROLOGY, 2008, 377 (02) : 364 - 378
  • [44] Longitudinal imaging of HIV-1 spread in humanized mice with parallel 3D immunofluorescence and electron tomography
    Kieffer, Collin
    Ladinsky, Mark S.
    Ninh, Allen
    Galimidi, Rachel P.
    Bjorkman, Pamela J.
    ELIFE, 2017, 6
  • [45] Stepping toward a Macaque Model of HIV-1 Induced AIDS
    Kimata, Jason T.
    VIRUSES-BASEL, 2014, 6 (09): : 3643 - 3651
  • [46] Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice
    Michael D Boska
    Prasanta K Dash
    Jaclyn Knibbe
    Adrian A Epstein
    Sidra P Akhter
    Natasha Fields
    Robin High
    Edward Makarov
    Stephen Bonasera
    Harris A Gelbard
    Larisa Y Poluektova
    Howard E Gendelman
    Santhi Gorantla
    Molecular Neurodegeneration, 9
  • [47] Diverse HIV-1 escape pathways from broadly neutralizing antibody PGDM1400 in humanized mice
    van der Velden, Yme U.
    Villaudy, Julien
    Siteur-van Rijnstra, Esther
    van der Linden, Cynthia A.
    Vink, Monique A.
    Schermer, Edith E.
    Weijer, Kees
    Berkhout, Ben
    Sanders, Rogier W.
    van Gils, Marit J.
    MABS, 2020, 12 (01)
  • [48] Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice
    Boska, Michael D.
    Dash, Prasanta K.
    Knibbe, Jaclyn
    Epstein, Adrian A.
    Akhter, Sidra P.
    Fields, Natasha
    High, Robin
    Makarov, Edward
    Bonasera, Stephen
    Gelbard, Harris A.
    Poluektova, Larisa Y.
    Gendelman, Howard E.
    Gorantla, Santhi
    MOLECULAR NEURODEGENERATION, 2014, 9 : 58
  • [49] Mechanistic differences between HIV-1 and SIV nucleocapsid proteins and cross-species HIV-1 genomic RNA recognition
    Post, Klara
    Olson, Erik D.
    Naufer, M. Nabuan
    Gorelick, Robert J.
    Rouzina, Ioulia
    Williams, Mark C.
    Musier-Forsyth, Karin
    Levin, Judith G.
    RETROVIROLOGY, 2016, 13
  • [50] Mechanistic differences between HIV-1 and SIV nucleocapsid proteins and cross-species HIV-1 genomic RNA recognition
    Klara Post
    Erik D. Olson
    M. Nabuan Naufer
    Robert J. Gorelick
    Ioulia Rouzina
    Mark C. Williams
    Karin Musier-Forsyth
    Judith G. Levin
    Retrovirology, 13