Viral evolution of SIV chimpanzee toward HIV-1 using humanized mice

被引：0
|
作者：
Curlin, James Z. [1 ,2 ]
Schmitt, Kimberly [1 ]
Remling-Mulder, Leila [1 ]
Tibbitts, Corina Valencia [3 ]
O'Connor, Shelby [3 ]
Marx, Preston [4 ,5 ]
Akkina, Ramesh [1 ,6 ]
机构：
[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO USA
[2] Univ Colorado Anschutz Med Campus, Dept Med, ADEAR Training Program, Aurora, CO USA
[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pathol & Lab Med, Madison, WI USA
[4] Sch Publ Hlth & Trop Med, Dept Trop Med, New Orleans, LA USA
[5] Tulane Natl Primate Res Ctr, Covington, LA USA
[6] Colorado State Univ, Dept Microbiol Immunol & Pathol, 1619 Campus Delivery, Ft Collins, CO 80521 USA
来源：
JOURNAL OF MEDICAL PRIMATOLOGY | 2023年 / 52卷 / 05期
关键词：
HIV-1; hu-HSC mice; serial passaging; SIVcpzMB897; viral evolution; MUCOSAL TRANSMISSION; ADAPTATION; VIRUS; MODEL;
D O I：
10.1111/jmp.12675
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4(+) T cell decline, and analyzing genetic changes. Four serial passages showed many non-synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.
引用
收藏
页码：294 / 297
页数：4
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