Viral evolution of SIV chimpanzee toward HIV-1 using humanized mice

被引：0

作者：

Curlin, James Z. ^{[1
,2
]}

Schmitt, Kimberly ^{[1
]}

Remling-Mulder, Leila ^{[1
]}

Tibbitts, Corina Valencia ^{[3
]}

O'Connor, Shelby ^{[3
]}

Marx, Preston ^{[4
,5
]}

Akkina, Ramesh ^{[1
,6
]}

机构：

[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO USA

[2] Univ Colorado Anschutz Med Campus, Dept Med, ADEAR Training Program, Aurora, CO USA

[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pathol & Lab Med, Madison, WI USA

[4] Sch Publ Hlth & Trop Med, Dept Trop Med, New Orleans, LA USA

[5] Tulane Natl Primate Res Ctr, Covington, LA USA

[6] Colorado State Univ, Dept Microbiol Immunol & Pathol, 1619 Campus Delivery, Ft Collins, CO 80521 USA

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 2023年 / 52卷 / 05期

关键词：

HIV-1; hu-HSC mice; serial passaging; SIVcpzMB897; viral evolution; MUCOSAL TRANSMISSION; ADAPTATION; VIRUS; MODEL;

D O I：

10.1111/jmp.12675

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4(+) T cell decline, and analyzing genetic changes. Four serial passages showed many non-synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.

引用

页码：294 / 297

页数：4

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