Determinants of incident atherosclerotic cardiovascular disease events among individuals with type 2 diabetic microvascular complications in the UK: a prospective cohort study

被引：2

作者：

Wang, Yaxin ^{[1
]}

Bulloch, Gabriella ^{[2
]}

Huang, Yu ^{[1
,3
]}

Liang, Yingying ^{[1
]}

Du, Zijing ^{[1
]}

Wu, Guanrong ^{[1
]}

Fang, Ying ^{[1
]}

Hu, Yijun ^{[1
]}

Shang, Xianwen ^{[1
,2
,3
]}

Zhu, Zhuoting ^{[1
,2
,3
]}

Zhang, Xiayin ^{[1
,3
]}

Yang, Xiaohong ^{[1
]}

Yu, Honghua ^{[1
,4
]}

机构：

[1] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Eye Inst, Guangdong Acad Med Sci,Dept Ophthalmol, Guangzhou, Peoples R China

[2] Royal Victorian Eye & Ear Hosp, Ctr Eye Res Australia, East Melbourne, Vic, Australia

[3] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Acad Med Sci, Guangzhou, Peoples R China

[4] Guangdong Prov Key Lab Artificial Intelligence Med, Guangzhou, Peoples R China

来源：

DIABETOLOGY & METABOLIC SYNDROME | 2023年 / 15卷 / 01期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Type; 2; diabetes; Microvascular complication; Atherosclerotic cardiovascular disease; High-density lipoprotein cholesterol; Lipoprotein(a); DENSITY-LIPOPROTEIN CHOLESTEROL; HDL CHOLESTEROL; UNITED-STATES; ALL-CAUSE; RISK; MECHANISMS; MORTALITY; MELLITUS; OUTCOMES; ASSOCIATIONS;

D O I：

10.1186/s13098-023-01152-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To evaluate the association of atherosclerotic cardiovascular disease (ASCVD) risk factors with incident ASCVD events among type 2 diabetes (T2D) individuals with microvascular complications.Methods We included T2D participants with only microvascular complications from the UK Biobank cohort at baseline (2006-2010). Multivariable-adjusted Cox proportional hazards models were used to study the association between ASCVD risk factors with adjudicated incident ASCVD in T2D participants with only microvascular complications. A restricted cubic spline approach was employed to evaluate potential nonlinear associations between ASCVD risk factors and ASCVD.Results We studied 4,129 T2D individuals with microvascular complications at baseline. Over a median follow-up of 11.7 years, a total of 1,180 cases of incident ASCVD were documented, of which 1,040 were CHD, 100 were stroke, and 40 were both CHD and stroke events. After multivariable-adjustment, high-density lipoprotein cholesterol (HDL-C) level was linearly associated with a decreased risk of incident ASCVD [hazard ratio (HR): 0.49, 95% Confidence interval (CI): 0.32-0.75, P-linear = 0.011] and each 10 nmol/L increase of lipoprotein(a) [Lp(a)] level (HR: 1.02, 95% CI: 1.00-1.04, P-linear = 0.012) was linearly associated with an increased risk of incident ASCVD in T2D participants with only microvascular complications.Conclusion HDL-C levels and Lp(a) levels (per 10 nmol/L) showed an independent linear relation with ASCVD risk among T2D individuals with only microvascular complications at long-term follow-up.

引用

页数：10

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