Surgical Intervention in Fibrous Dysplasia

Surgical Intervention in Fibrous Dysplasia Fibrous dysplasia is a rare bone disease with a wide clinical spectrum of manifestations in adults and children. The complex alteration of bone very commonly results in fractures and deformities in children and chronic, weight-bearing pain in adults. Despite advances in understanding the pathogenesis of fibrous dysplasia, its treatment is not clear and is still controversial. Over the past three decades, there have been advances in both surgical and drug treatment options. The goal of therapy must be to prevent deformity, fracture, and chronic pain. In the past, fibrous dysplasia was treated exclusively surgically, mainly by curettage of the lesions. Autologous bone grafting has been shown to have little success, whereas the use of allogeneic cortical strout grafts appears to be beneficial. The use of intramedullary osteosyntheses is preferable to plate and screw osteosyntheses. The treatment of each patient must be individualized after consultation with the patient. Antiresorptive therapies have provided benefits in terms of bone pain and fractures in small studies.