Multi-organelle-targeting pH-dependent NIR fluorescent probe for lysosomal viscosity

被引：28
作者：
Wang, Huili [1 ,2 ]
Sun, Yishuo [3 ,4 ]
Lin, Xuemei [1 ,2 ]
Feng, Wei [3 ,4 ]
Li, Zhanxian [1 ,2 ]
Yu, Mingming [1 ,2 ]
机构：
[1] Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China
[2] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China
[3] Fudan Univ, Inst Biomed Sci, Dept Chem, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China
[4] Fudan Univ, Collaborat Innovat Ctr Chem Energy Mat, Shanghai 200433, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2023年 / 34卷 / 03期
基金：
中国国家自然科学基金;
关键词：
NIR; Lysosomal viscosity; PH-dependent; Multi-organelle localization; MITOCHONDRIA;
D O I：
10.1016/j.cclet.2022.06.049
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The normal operation of lysosome, mitochondria, Golgi apparatus and endoplasmic reticulum plays a significant role in maintaining cell homeostasis. Reflecting the state and function of lysosomes, viscosity is a pivotal parameter to assess the stability of microenvironment. Herein, based on TICT mechanism, a new NIR pH-dependent fluorescent probe DCIC with push-pull electronic moiety was synthesized to identify the lysosomes viscosity. In viscous media, DCIC was highly sensitive to viscosity, fluorescence intensity increased by 180 times as viscosity increased from 1.0 cp to 438.4 cp. In addition, DCIC have high localization ability for lysosome, mitochondria, Golgi apparatus, and endoplasmic reticulum and can monitor lysosomal viscosity fluctuations with laser confocal microscopy.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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页数：5
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