Synthesis and in vitro evaluation of Ca-P coating on biodegradable Zn alloys

The burst release of Zn2 + from the naked pure Zn and Zn-based alloys could induce local and sys-temic toxicity, which limits their clinical applications as biodegradable implants. In order to inhibit the explosive release of zinc ions, a protective Ca-P coating was synthesized on biodegradable Zn al-loy. The microstructure, corrosion resistance, antibacterial activity, and biosafety of the Ca-P coating are systematically investigated. Electrochemical tests revealed that Ca-P protective layer has enhanced the anti-corrosion behavior of Zn alloy. Furthermore, Ca-P protective layer showed good biocompatibility, as demonstrated by significantly increased cell viability, good attachment, and spreading at a higher cell density. Besides, the Ca-P coating could also retain the antibacterial ability and inhibit the bacterial ad-hesion. The Ca-P protective layer synthesized on biodegradable Zn alloy can be considered and applied in future biomedical applications.(c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.