Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study

被引：28

作者：

Pingault, Jean-Baptiste ^{[1
,2
]}

Barkhuizen, Wikus ^{[1
]}

Wang, Biyao ^{[1
]}

Hannigan, Laurie J. ^{[3
,4
,5
,6
]}

Eilertsen, Espen Moen ^{[7
,8
]}

Corfield, Elizabeth ^{[3
,4
]}

Andreassen, Ole A. ^{[9
,10
]}

Ask, Helga ^{[4
,7
]}

Tesli, Martin ^{[4
,9
,10
]}

Askeland, Ragna Bugge ^{[4
,5
,9
,10
]}

Smith, George Davey ^{[5
,6
]}

Stoltenberg, Camilla ^{[11
,12
]}

Davies, Neil M. ^{[5
,6
,13
]}

Reichborn-Kjennerud, Ted ^{[4
,10
,14
]}

Ystrom, Eivind ^{[4
,7
,15
]}

Havdahl, Alexandra ^{[3
,4
,5
,6
,7
]}

机构：

[1] UCL, Div Psychol & Language Sci, London, England

[2] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London, England

[3] Lovisenberg Diaconal Hosp, Nic Waals Inst, Oslo, Norway

[4] Norwegian Inst Publ Hlth, Dept Mental Disorders, Oslo, Norway

[5] Univ Bristol, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England

[6] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England

[7] Univ Oslo, PROMENTA Res Ctr, Dept Psychol, Oslo, Norway

[8] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Oslo, Norway

[9] Univ Oslo, NORMENT Ctr, Inst Clin Med, Oslo, Norway

[10] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway

[11] Norwegian Inst Publ Hlth, Oslo, Norway

[12] Univ Bergen, Bergen, Norway

[13] Norwegian Univ Sci & Technol, NTNU, Dept Publ Hlth & Nursing, KG Jebsen Ctr Genet Epidemiol, Trondheim, Norway

[14] Univ Oslo, Inst Clin Med, Oslo, Norway

[15] Univ Oslo, Sch Pharm, Oslo, Norway

来源：

MOLECULAR PSYCHIATRY | 2023年 / 28卷 / 04期

基金：

英国惠康基金; 英国医学研究理事会; 欧洲研究理事会;

关键词：

MATERNAL ALCOHOL-USE; PARENTAL PSYCHOPATHOLOGY; OFFSPRING ADHD; DISORDER; ASSOCIATION; DEPRESSION; PREGNANCY; SYMPTOMS; BEHAVIOR; PROFILE;

D O I：

10.1038/s41380-022-01863-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Identifying mechanisms underlying the intergenerational transmission of risk for attention-deficit/hyperactivity disorder (ADHD) traits can inform interventions and provide insights into the role of parents in shaping their children's outcomes. We investigated whether genetic transmission and genetic nurture (environmentally mediated effects) underlie associations between polygenic scores indexing parental risk and protective factors and their offspring's ADHD traits. This birth cohort study included 19,506 genotyped mother-father-offspring trios from the Norwegian Mother, Father and Child Cohort Study. Polygenic scores were calculated for parental factors previously associated with ADHD, including psychopathology, substance use, neuroticism, educational attainment, and cognitive performance. Mothers reported on their 8-year-old children's ADHD traits (n = 9,454 children) using the Parent/Teacher Rating Scale for Disruptive Behaviour Disorders. We found that associations between ADHD maternal and paternal polygenic scores and child ADHD traits decreased significantly when adjusting for the child polygenic score (p(Delta beta) = 9.95 x 10(-17) for maternal and p(Delta beta) = 1.48 x 10(-14) for paternal estimates), suggesting genetic transmission of ADHD risk. Similar patterns suggesting genetic transmission of risk were observed for smoking, educational attainment, and cognition. The maternal polygenic score for neuroticism remained associated with children's ADHD ratings even after adjusting for the child polygenic score, indicating genetic nurture. There was no robust evidence of genetic nurture for other parental factors. Our findings indicate that the intergenerational transmission of risk for ADHD traits is largely explained by the transmission of genetic variants from parents to offspring rather than by genetic nurture. Observational associations between parental factors and childhood ADHD outcomes should not be interpreted as evidence for predominantly environmentally mediated effects.

引用

页码：1731 / 1738

页数：8

共 66 条

[1] The Nature of Nurture: Using a Virtual-Parent Design to Test Parenting Effects on Children's Educational Attainment in Genotyped Families [J].