Challenges and Opportunities of Functionalized Cucurbiturils for Biomedical Applications

被引：53

作者：

Yin, Hang ^{[1
]}

Cheng, Qian ^{[1
]}

Bardelang, David ^{[2
]}

Wang, Ruibing ^{[1
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macau, Peoples R China

[2] Aix Marseille Univ, CNRS, ICR, F-13013 Marseille, France

来源：

JACS AU | 2023年 / 3卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Macrocycles; Cucurbiturils; Functionalization; Biomedical application; Supramolecular Biomaterials; HOST-GUEST COMPLEXES; POLYMER NANOCAPSULES; MOLECULAR RECOGNITION; CONTROLLED-RELEASE; HIGH-AFFINITY; FRET PAIR; MACROCYCLE; BINDING; WATER; DRUG;

D O I：

10.1021/jacsau.3c00273

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cucurbit[n]uril (CB[n]) macrocycles (especially CB[5] to CB[8]) have shown exceptional attributes since their discovery in 2000. Their stability, water solubility, responsiveness to several stimuli, and remarkable binding properties have enabled a growing number of biological applications. Yet, soon after their discovery, the challenge of their functionalization was set. Nevertheless, after more than two decades, a myriad of CB[n] derivatives has been described, many of them used in cells or in vivo for advanced applications. This perspective summarizes key advances of this burgeoning field and points to the next opportunities and remaining challenges to fully express the potential of these fascinating macrocycles in biology and biomedical sciences.

引用

页码：2356 / 2377

页数：22

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