Enzyme-Instructed Aggregation/Dispersion of Fluorophores for Near-Infrared Fluorescence Imaging In Vivo

被引：7
作者：
Zhang, Zhipeng [1 ]
Chen, Peiyao [2 ]
Sun, Yao [3 ]
机构：
[1] Hubei Univ Sci & Technol, Xianning Med Coll, Xianning 437000, Peoples R China
[2] Hubei Univ Technol, Natl 111 Ctr Cellular Regulat & Mol Pharmaceut, Sch Food & Biol Engn, Key Lab Fermentat Engn,Minist Educ,Hubei Key Lab I, Wuhan 430068, Peoples R China
[3] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China
来源：
MOLECULES | 2023年 / 28卷 / 14期
关键词：
near-infrared fluorescence; enzyme; activatable probe; MATRIX-METALLOPROTEINASE; CANCER-CELLS; PROBE; NANOPARTICLES; CHEMOTHERAPY; TUMOR; TRACKING;
D O I：
10.3390/molecules28145360
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Near-infrared (NIR) fluorescence is a noninvasive, highly sensitive, and high-resolution modality with great potential for in vivo imaging. Compared with "Always-On" probes, activatable NIR fluorescent probes with "Turn-Off/On" or "Ratiometric" fluorescent signals at target sites exhibit better signal-to-noise ratio (SNR), wherein enzymes are one of the ideal triggers for probe activation, which play vital roles in a variety of biological processes. In this review, we provide an overview of enzyme-activatable NIR fluorescent probes and concentrate on the design strategies and sensing mechanisms. We focus on the aggregation/dispersion state of fluorophores after the interaction of probes and enzymes and finally discuss the current challenges and provide some perspective ideas for the construction of enzyme-activatable NIR fluorescent probes.
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收藏
页数：17
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