Prevalence and molecular analysis of glucose-6-phosphate dehydrogenase deficiency in Chin State, Myanmar

被引：1

作者：

Aung, Ja Moon ^{[1
]}

Moon, Zin ^{[1
]}

VanBik, Dorene ^{[1
]}

Dinzouna-Boutamba, Sylvatrie-Danne ^{[1
]}

Lee, Sanghyun ^{[2
]}

Ring, Zau ^{[3
]}

Chung, Dong-Il ^{[1
]}

Hong, Yeonchul ^{[1
]}

Goo, Youn-Kyoung ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Parasitol & Trop Med, Daegu 41944, South Korea

[2] Korea Dis Control & Prevent Agcy, Korea Natl Inst Hlth, Dept Precis Med, Div Healthcare & Artificial Intelligence, Cheongju 28159, South Korea

[3] Kachin State Publ Hlth Dept, Vector Borne Dis Control Unit, Myitkyina, Myanmar

来源：

PARASITES HOSTS AND DISEASES | 2023年 / 61卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Glucose-6-phosphate dehydrogenase deficiency; variant; Chin State; Myan-mar; G6PD DEFICIENCY; MUTATIONS; VARIANTS; POPULATIONS; SEQUENCE;

D O I：

10.3347/PHD.23004

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is caused by X-linked reces-sive disorderliness. It induces severe anemia when a patient with G6PD deficiency is ex-posed to oxidative stress that occurs with administration of an antimalarial drug, prima-quine. The distribution of G6PD deficiency remains unknown while primaquine has been used for malaria treatment in Myanmar. This study aimed to investigate the prevalence of G6PD deficiency and its variants in Chin State, Myanmar. Among 322 participants, 18 (11 males and 7 females) demonstrated a G6PD deficiency. Orissa variant was dominant in the molecular analysis. This would be related to neighboring Indian and Bangladeshi population, in which Orissa variant was also reported as the main mutation type. The screening test for G6PD deficiency before primaquine treatment appears to be impor-tant in Myanmar.

引用

页码：154 / +

页数：10

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