Boron uptake of boronophenylalanine and the effect of boron neutron capture therapy in cervical cancer cells

被引：4
作者：
Terada, Shinichi [1 ,4 ]
Tsunetoh, Satoshi [1 ]
Tanaka, Yoshimichi [1 ]
Tanaka, Tomohito [1 ]
Kashiwagi, Hideki [2 ]
Takata, Takushi [3 ]
Kawabata, Shinji [2 ]
Suzuki, Minoru [3 ]
Ohmichi, Masahide [1 ]
机构：
[1] Osaka Med & Pharmaceut Univ, Dept Obstet & Gynecol, Takatsuki, Japan
[2] Osaka Med & Pharmaceut Univ, Dept Neurosurg, Takatsuki, Japan
[3] Kyoto Univ, Inst Integrated Radiat & Nucl Sci, Asasiro Nishi,Kumatori Cho, Kyoto, Japan
[4] Osaka Med & Pharmaceut Univ, Dept Obstet & Gynecol, 2-7 Daigaku Machi, Takatsuki, Osaka 5690801, Japan
来源：
APPLIED RADIATION AND ISOTOPES | 2023年 / 197卷
关键词：
Neutron capture therapy; Cervical cancer; Boron concentration; ACID TRANSPORTER 1; PROGNOSTIC-SIGNIFICANCE; LAT1; EXPRESSION; RADIOTHERAPY; CARCINOMA; RECURRENT; BIODISTRIBUTION; PHENYLALANINE; DELIVERY; HEAD;
D O I：
10.1016/j.apradiso.2023.110792
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
There are few studies about boron neutron capture therapy (BNCT) for cervical cancer. The present study evaluated the biodistribution of boronophenylalanine (BPA) and the effect of BNCT on cervical cancer cell lines. BPA exposure and neutron irradiation of cervical cancer cell lines resulted in decreased survival fraction compared to irradiation only. In vivo cervical cancer tumor boron concentration was highest at 2.5 h after BPA intraperitoneal administration, and higher than in the other organs. BNCT may be effective against cervical carcinoma.
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页数：7
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