Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?

被引：5
作者：
Tibrewal, Prashant [1 ,2 ]
Nair, Pramod C. [3 ,4 ]
Gregory, Karen J. [5 ,6 ]
Langmead, Christopher J. [5 ,6 ]
Chan, Sherry Kit Wa [7 ,8 ]
Bastiampillai, Tarun [9 ,10 ]
机构：
[1] Queen Elizabeth Hosp, Cramond Clin, Woodville South, SA 5011, Australia
[2] Univ Adelaide, Discipline Psychiat, Adelaide, SA, Australia
[3] Flinders Univ S Australia, Flinders Hlth & Med Res Inst FHMRI, Discipline Clin Pharmacol, Coll Med & Publ Hlth, Adelaide, SA, Australia
[4] Univ Adelaide, South Australian Hlth & Med Res Inst SAHMRI, Adelaide, SA, Australia
[5] Monash Univ, Monash Inst Pharmaceut Sci, Drug Discovery Biol, 381 Royal Parade, Parkville, VIC 3052, Australia
[6] Monash Univ, Monash Inst Pharmaceut Sci, ARC Ctr Cryo electron Microscopy Membrane Prot, 381 Royal Parade, Parkville, VIC 3052, Australia
[7] Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China
[8] Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Peoples R China
[9] Flinders Univ S Australia, Coll Med & Publ Hlth, Discipline Psychiat, Adelaide, SA, Australia
[10] Monash Univ, Dept Psychiat, Wellington Rd, Clayton 3800, Australia
来源：
MOLECULAR PSYCHIATRY | 2023年 / 28卷 / 05期
关键词：
TREATMENT RESISTANCE; SCHIZOPHRENIA; PSYCHOSIS; CORTEX;
D O I：
10.1038/s41380-023-02026-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Behavioural supersensitivity may be a result of increased glutamate sensitivity of D2-MSN and reduced sensitivity to dopamine. We propose that clozapine may address behavioural supersensitivity by modulating glutamate activity which may partially explain its unique effectiveness in the setting of treatment resistant schizophrenia.
引用
收藏
页码：1839 / 1842
页数：4
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