Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic

被引：83

作者：

Oudit, Gavin Y. ^{[1
,2
]}

Wang, Kaiming ^{[1
,2
]}

Viveiros, Anissa ^{[1
,2
]}

Kellner, Max J. ^{[3
]}

Penninger, Josef M. ^{[3
,4
]}

机构：

[1] Univ Alberta, Dept Med, Div Cardiol, Edmonton, AB, Canada

[2] Univ Alberta, Mazankowski Alberta Heart Inst, Edmonton, AB, Canada

[3] Austrian Acad Sci, Inst Mol Biotechnol, Vienna, Austria

[4] Univ British Columbia, Life Sci Inst, Dept Med Genet, Vancouver, BC, Canada

来源：

CELL | 2023年 / 186卷 / 05期

基金：

欧盟地平线“2020”;

关键词：

CLINICAL CHARACTERISTICS; HOSPITALIZED-PATIENTS; RENIN-ANGIOTENSIN; OXIDATIVE STRESS; MYOCARDIAL ACE2; SPIKE PROTEIN; INFLAMMATION; RECEPTOR; HYPERTROPHY; METHYLATION;

D O I：

10.1016/j.cell.2023.01.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the COVID-19 pandemic, it has become one of the most therapeutically targeted human molecules in biomedicine. ACE2 serves two fundamental physiological roles: as an enzyme, it alters peptide cascade balance; as a chap-erone, it controls intestinal amino acid uptake. ACE2's tissue distribution, affected by co-morbidities and sex, explains the broad tropism of coronaviruses and the clinical manifestations of SARS and COVID-19. ACE2-based therapeutics provide a universal strategy to prevent and treat SARS-CoV-2 infections, appli-cable to all SARS-CoV-2 variants and other emerging zoonotic coronaviruses exploiting ACE2 as their cellular receptor.

引用

页码：906 / 922

页数：17

共 160 条

[41] SARS-CoV-2 infection and replication in human gastric organoids [J].

Giobbe, Giovanni Giuseppe ;

Bonfante, Francesco ;

Jones, Brendan C. ;

Gagliano, Onelia ;

Luni, Camilla ;

Zambaiti, Elisa ;

Perin, Silvia ;

Laterza, Cecilia ;

Busslinger, Georg ;

Stuart, Hannah ;

Pagliari, Matteo ;

Bortolami, Alessio ;

Mazzetto, Eva ;

Manfredi, Anna ;

Colantuono, Chiara ;

Di Filippo, Lucio ;

Pellegata, Alessandro Filippo ;

Panzarin, Valentina ;

Thapar, Nikhil ;

Li, Vivian Sze Wing ;

Eaton, Simon ;

Cacchiarelli, Davide ;

Clevers, Hans ;

Elvassore, Nicola ;

De Coppi, Paolo .

NATURE COMMUNICATIONS, 2021, 12 (01)

[42] Engineered ACE2 receptor traps potently neutralize SARS-CoV-2 [J].

Glasgow, Anum ;

Glasgow, Jeff ;

Limonta, Daniel ;

Solomon, Paige ;

Lui, Irene ;

Zhang, Yang ;

Nix, Matthew A. ;

Rettko, Nicholas J. ;

Zha, Shoshana ;

Yamin, Rachel ;

Kao, Kevin ;

Rosenberg, Oren S. ;

Ravetch, Jeffrey V. ;

Wiita, Arun P. ;

Leung, Kevin K. ;

Lim, Shion A. ;

Zhou, Xin X. ;

Hobman, Tom C. ;

Kortemme, Tanja ;

Wells, James A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (45) :28046-28055

[43] Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63 [J].

Glowacka, Ilona ;

Bertram, Stephanie ;

Herzog, Petra ;

Pfefferle, Susanne ;

Steffen, Imke ;

Muench, Marcus O. ;

Simmons, Graham ;

Hofmann, Heike ;

Kuri, Thomas ;

Weber, Friedemann ;

Eichler, Jutta ;

Drosten, Christian ;

Poehlmann, Stefan .

JOURNAL OF VIROLOGY, 2010, 84 (02) :1198-1205

[44] Clinical Characteristics of Coronavirus Disease 2019 in China [J].

Guan, W. ;

Ni, Z. ;

Hu, Yu ;

Liang, W. ;

Ou, C. ;

He, J. ;

Liu, L. ;

Shan, H. ;

Lei, C. ;

Hui, D. S. C. ;

Du, B. ;

Li, L. ;

Zeng, G. ;

Yuen, K. -Y. ;

Chen, R. ;

Tang, C. ;

Wang, T. ;

Chen, P. ;

Xiang, J. ;

Li, S. ;

Wang, Jin-lin ;

Liang, Z. ;

Peng, Y. ;

Wei, L. ;

Liu, Y. ;

Hu, Ya-hua ;

Peng, P. ;

Wang, Jian-ming ;

Liu, J. ;

Chen, Z. ;

Li, G. ;

Zheng, Z. ;

Qiu, S. ;

Luo, J. ;

Ye, C. ;

Zhu, S. ;

Zhong, N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (18) :1708-1720

[45] Evolutionary Arms Race between Virus and Host Drives Genetic Diversity in Bat Severe Acute Respiratory Syndrome-Related Coronavirus Spike Genes [J].

Guo, Hua ;

Hu, Bing-Jie ;

Yang, Xing-Lou ;

Zeng, Lei-Ping ;

Li, Bei ;

Ouyang, Songying ;

Shi, Zheng-Li .

JOURNAL OF VIROLOGY, 2020, 94 (20)

[46] Emergence and widespread circulation of a recombinant SARS-CoV-2 lineage in North America [J].

Gutierrez, Bernardo ;

Castelan Sanchez, Hugo G. ;

Candido, Darlan da Silva ;

Jackson, Ben ;

Fleishon, Shay ;

Houzet, Renaud ;

Ruis, Christopher ;

Delaye, Luis ;

Faria, Nuno R. ;

Rambaut, Andrew ;

Pybus, Oliver G. ;

Escalera-Zamudio, Marina .

CELL HOST & MICROBE, 2022, 30 (08) :1112-+

[47] Increased urinary angiotensin converting enzyme 2 and neprilysin in patients with type 2 diabetes [J].

Gutta, Sridevi ;

Grobe, Nadja ;

Kumbaji, Meenasri ;

Osman, Hassan ;

Saklayen, Mohammad ;

Li, Gengxin ;

Elased, Khalid M. .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2018, 315 (02) :F263-F274

[48] Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5 [J].

Hachmann, Nicole P. ;

Miller, Jessica ;

Collier, Ai-ris Y. ;

Ventura, John D. ;

Yu, Jingyou ;

Rowe, Marjorie ;

Bondzie, Esther A. ;

Powers, Olivia ;

Surve, Nehalee ;

Hall, Kevin ;

Barouch, Dan H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (01) :86-88

[49] Modulation of TNF-α-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-α production and facilitates viral entry [J].

Haga, Shiori ;

Yamamoto, Norio ;

Nakai-Murakami, Chikako ;

Osawa, Yoshiaki ;

Tokunaga, Kenzo ;

Sata, Tetsutaro ;

Yamamoto, Naoki ;

Sasazuki, Takehiko ;

Ishizaka, Yukihito .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (22) :7809-7814

[50] SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters [J].

Halfmann, Peter J. ;

Iida, Shun ;

Iwatsuki-Horimoto, Kiyoko ;

Maemura, Tadashi ;

Kiso, Maki ;

Scheaffer, Suzanne M. ;

Darling, Tamarand L. ;

Joshi, Astha ;

Loeber, Samantha ;

Singh, Gagandeep ;

Foster, Stephanie L. ;

Ying, Baoling ;

Case, James Brett ;

Chong, Zhenlu ;

Whitener, Bradley ;

Moliva, Juan ;

Floyd, Katharine ;

Ujie, Michiko ;

Nakajima, Noriko ;

Ito, Mutsumi ;

Wright, Ryan ;

Uraki, Ryuta ;

Warang, Prajakta ;

Gagne, Matthew ;

Li, Rong ;

Sakai-Tagawa, Yuko ;

Liu, Yanan ;

Larson, Deanna ;

Osorio, Jorge E. ;

Hernandez-Ortiz, Juan P. ;

Henry, Amy R. ;

Ciuoderis, Karl ;

Florek, Kelsey R. ;

Patel, Mit ;

Odle, Abby ;

Wong, Lok-Yin Roy ;

Bateman, Allen C. ;

Wang, Zhongde ;

Edara, Venkata-Viswanadh ;

Chong, Zhentu ;

Franks, John ;

Jeevan, Trushar ;

Fabrizio, Thomas ;

DeBeauchamp, Jennifer ;

Kercher, Lisa ;

Seiler, Patrick ;

Gonzalez-Reiche, Ana Silvia ;

Sordillo, Emilia Mia ;

Chang, Lauren A. ;

van Baker, Harm .

NATURE, 2022, 603 (7902) :687-+

← 1 2 3 4 5 6 7 8 9 10 →