Oxidative stress in cerebrovascular disease and associated diseases

被引:25
作者
Kumar, Vijay [1 ]
Bishayee, Kausik [2 ]
Park, Soochul [3 ]
Lee, Unjoo [4 ]
Kim, Jaebong [1 ]
机构
[1] Hallym Univ, Inst Cell Differentiat & Aging, Dept Biochem, Coll Med, Chunchon, South Korea
[2] Soonchunhyang Univ, Soonchunhyang Inst Med Bio Sci, Biomed Sci Core Facil, Cheonan, South Korea
[3] Sookmyung Womens Univ, Dept Biol Sci, Seoul, South Korea
[4] Hallym Univ, Dept Elect Engn, Chunchon, South Korea
基金
新加坡国家研究基金会;
关键词
oxidative stress; neurodegeneration; stroke; risk factors; hypertension; ISCHEMIC-STROKE; CARDIOVASCULAR-DISEASE; HERBAL MEDICINE; RISK-FACTORS; PATHOGENESIS; BRAIN; HYPERTENSION; MECHANISMS; INJURY; GENE;
D O I
10.3389/fendo.2023.1124419
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cellular aging is the most severe risk factor for neurodegenerative disease. Simultaneously, oxidative stress (OS) is a critical factor in the aging process, resulting from an imbalance between reactive oxygen and nitrogen species and the antioxidant defense system. Emerging evidence indicates that OS is a common cause of several age-related brain pathologies, including cerebrovascular diseases. Elevated OS disrupts endothelial functional ability by diminishing the bioavailability of nitric oxide (a vascular dilator), induces atherosclerosis, and impairs vasculature, which are all common characteristics of cerebrovascular disease. In this review, we summarize evidence supporting an active role of OS in cerebrovascular disease progression, focusing primarily on stroke pathogenesis. We briefly discuss hypertension, diabetes, heart disease, and genetic factors that are often linked to OS and are considered associated factors influencing stroke pathology. Finally, we discuss the current pharmaceutics/therapeutics available for treating several cerebrovascular diseases.
引用
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页数:7
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